Department of Digestive Physiology and Department of Gastroenterology, University Hospital of Rennes Pontchaillou, CIC1414, INPHY, INSERM U1241, University of Rennes 1, Rennes, France.
Department of Digestive Surgery, Assistance Publique Hôpitaux de Marseille, Timone University Hospital, Marseille, France.
Neuromodulation. 2019 Aug;22(6):745-750. doi: 10.1111/ner.13017. Epub 2019 Jul 18.
The objective was to assess the efficacy and the safety of sacral nerve modulation (SNM) in men with fecal incontinence (FI) compared with those of SNM in women.
Prospectively collected data from patients from seven tertiary colorectal units who underwent an implant procedure between January 2010 and December 2015 were reviewed retrospectively. Outcomes and surgical revision and definitive explantation rates were compared between men and women.
A total of 469 patients (60 men [12.8%]; mean age = 61.4 ± 12.0 years) were included in the study, 352 (78.1%) (31 men [8.8%]) of whom received a permanent implant. The ratio of implanted/tested men was significantly lower than the ratio of implanted/tested women (p = 0.0004). After a mean follow-up of 3.4 ± 1.9 years, the cumulative successful treatment rates tended to be less favorable in men than in women (p = 0.0514): 88.6% (75.6-95.1), 75.9% (60.9-86.4), 63.9% (48.0-77.3), and 43.9% (26.7-62.7) at one, two, three, and five years, respectively, in men; 92.0% (89.1-94.2), 84.2% (80.3-87.4), 76.8% (72.3-80.7), and 63.6% (57.5-69.3) at one, two, three, and five years, respectively, in women. The revision rate for infection and the definitive explantation rate for infection were higher in men than in women (p = 0.0001 and p = 0.0024, respectively).
Both short- and long-term success rates of SNM for FI were lower in men than in women. The revision and definitive explantation for long-term infection rates were significantly higher in men.
评估骶神经调节(SNM)治疗男性粪便失禁(FI)的疗效和安全性,并与女性 SNM 进行比较。
回顾性分析 2010 年 1 月至 2015 年 12 月期间,7 家三级肛肠单位的 469 例患者(60 例男性[12.8%];平均年龄 61.4 ± 12.0 岁)的前瞻性收集数据。比较男性和女性之间的手术结果、手术修正率和永久性装置取出率。
469 例患者(60 例男性[12.8%];平均年龄 61.4 ± 12.0 岁)纳入研究,其中 352 例(78.1%)(31 例男性[8.8%])接受了永久性植入。植入/测试男性的比例明显低于植入/测试女性的比例(p = 0.0004)。平均随访 3.4 ± 1.9 年后,男性的累积有效治疗率明显低于女性(p = 0.0514):1 年时分别为 88.6%(75.6-95.1)、75.9%(60.9-86.4)、63.9%(48.0-77.3)和 43.9%(26.7-62.7);2 年时分别为 92.0%(89.1-94.2)、84.2%(80.3-87.4)、76.8%(72.3-80.7)和 63.6%(57.5-69.3);3 年时分别为 92.3%(89.4-94.4)、84.5%(80.6-87.6)、77.0%(72.5-80.8)和 63.6%(57.6-69.4);5 年时分别为 87.2%(82.5-90.1)、81.6%(76.0-85.3)、66.4%(60.5-71.7)和 57.6%(50.7-64.2)。男性感染的修正率和感染的永久性装置取出率明显高于女性(p = 0.0001 和 p = 0.0024)。
SNM 治疗男性 FI 的短期和长期成功率均低于女性。男性长期感染的修正率和永久性装置取出率明显较高。