Nemchinskaia V L
Tsitologiia. 1988 Feb;30(2):115-26.
In addition to its well established role as a cofactor in redox reactions, NAD+ serves also as a substrate for a ubiquitous group of enzymes called ADP-ribosyltransferases. These enzymes are found in the cytosol and in the nucleus of eukaryotic cells, they are involved as components of pathogenic bacterial toxins, and as part of a mechanism for inactivating host cell protein biosynthetic machinery in bacteriophage-infected cells. An overview of mono(ADP)ribosylation reactions is provided.
除了作为氧化还原反应中的一种辅助因子这一已确立的作用外，NAD+还作为一类普遍存在的酶——ADP核糖基转移酶的底物。这些酶存在于真核细胞的细胞质和细胞核中，它们作为致病细菌毒素的成分发挥作用，并且在噬菌体感染的细胞中作为使宿主细胞蛋白质生物合成机制失活的一种机制的一部分。本文提供了单（ADP）核糖基化反应的概述。
