母体外源物质代谢基因多态性与胎儿生长受限风险的关联。
Association of maternal xenobiotic-metabolizing gene polymorphisms with risk of fetal growth restriction.
机构信息
Department of Obstetrics & Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
出版信息
Per Med. 2019 Jul;16(4):269-276. doi: 10.2217/pme-2018-0125. Epub 2019 Jul 19.
We investigated the association of maternal MspI, Ile462Val, null, null and Pro187Ser polymorphisms with fetal growth restriction risk. The polymorphisms were genotyped on 1842 mothers (N = 921 with fetal growth restriction and N = 921 controls). Odds ratios were calculated to estimate the risk. None of the five polymorphisms were associated with risk of fetal growth restriction among never-smoker mothers. However, the variant genotypes of MspI and null polymorphisms were associated with an increased risk of fetal growth restriction among mothers who were either passive or active smokers. MspI and null polymorphisms may interact with cigarette smoking to result in an increased risk of fetal growth restriction.
我们研究了母体 MspI、Ile462Val、null、null 和 Pro187Ser 多态性与胎儿生长受限风险的关联。在 1842 位母亲（N=921 例胎儿生长受限和 N=921 例对照）中对这些多态性进行了基因分型。计算比值比以估计风险。在从不吸烟者母亲中，这 5 种多态性均与胎儿生长受限的风险无关。然而，在被动或主动吸烟者中，MspI 和 null 多态性的变异基因型与胎儿生长受限的风险增加相关。MspI 和 null 多态性可能与吸烟相互作用，导致胎儿生长受限风险增加。
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