Shimizu K, Hokano M
Department of Anatomy, Tokyo Medical College, Japan.
Acta Histochem. 1988;83(1):65-70. doi: 10.1016/S0065-1281(88)80073-4.
After amyloid had deposited in the perifollicular area, cells contained iron disappeared in the red pulp but remained in the lymphoid follicles. Red blood cells must pass a slit of amyloid in the perifollicular area. Red blood cells become mechanically more fragile as they age. Hemoglobin in the serum is not engulfed by splenic macrophages. Disappearance of cells contained iron in the red pulp indicated that old or worn red blood cells are eliminated more by mechanical stress than by phagocytosis of macrophage in the senile spleen having amyloid deposition.
淀粉样物质沉积于滤泡周围区域后，含铁血细胞在红髓中消失，但仍存在于淋巴滤泡中。红细胞必须通过滤泡周围区域的淀粉样物质裂隙。随着红细胞老化，其机械脆性增加。血清中的血红蛋白不会被脾巨噬细胞吞噬。红髓中含铁血细胞的消失表明，在有淀粉样物质沉积的老年脾脏中，衰老或磨损的红细胞更多地是通过机械应力而非巨噬细胞的吞噬作用被清除。
