Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Eur Neuropsychopharmacol. 2019 Sep;29(9):1033-1040. doi: 10.1016/j.euroneuro.2019.06.011. Epub 2019 Jul 15.
The current study aimed to identify alterations in brain activation and connectivity related to nociceptive processing and pain sensitization in major depressive disorder (MDD), using repetitive heat pain stimulation during functional magnetic resonance imaging (fMRI) in 37 MDD patients and 33 healthy controls. Regional activation did not differ between groups, but functional connectivity was significantly decreased in MDD in a neural network connecting frontal, temporal and occipital areas (family-wise error-corrected p = 0.045). Supporting analyses suggested a significant association between network connectivity and trait neuroticism (p = 0.007) but not with the clinical state or familiar risk of MDD (all p values > 0.13). Our data relate a network-based phenotype for altered pain processing and antinociceptive control to MDD and encourage future studies on the shared intermediate neural psychological risk architecture of MDD and chronic pain.
本研究旨在利用功能磁共振成像（fMRI）在 37 名重度抑郁症（MDD）患者和 33 名健康对照者中进行重复热痛刺激，以确定与伤害性感受处理和痛觉敏化相关的大脑激活和连接的变化。两组之间的区域激活没有差异，但在连接额、颞和枕叶区域的神经网络中，MDD 的功能连接显著降低（校正后的家族性错误 p=0.045）。支持性分析表明，网络连接与特质神经质显著相关（p=0.007），但与临床状态或 MDD 的家族风险无关（所有 p 值均>0.13）。我们的数据将与 MDD 相关的疼痛处理和抗伤害控制的基于网络的表型与 MDD 联系起来，并鼓励未来对 MDD 和慢性疼痛的共同中间神经心理风险结构进行研究。
