Izumi T
Department of Urology, Osaka Medical School.
Hinyokika Kiyo. 1988 Jan;34(1):37-45.
To evaluate the preventive effect of continuous infusion on the nephrotoxicity of high-dose cisplatin (CDDP), the renal function was monitored in rabbits treated with this antineoplastic agent in various modes of administration. 131I-hippuran uptake of the renal cortical slices and histopathological examination as well as serum creatinine and BUN levels were used as parameters for assessing renal damage. When CDDP was administered at a dose of 3 mg/kg, continuous infusion showed a similar effect in the reduction of nephrotoxicity to the obtained from rapid infusion with mannitol diuresis. For the large dose of 6 mg/kg, only the combination of continuous infusion and mannitol diuresis significantly reduced the nephrotoxicity. When 3 mg/kg of CDDP was serially given once a week for 5 consecutive weeks, continuous infusion produced a similar or even more beneficial effect compared to rapid infusion with mannitol diuresis and maximum effect was observed in continuous infusion with concomitant mannitol diuresis. In conclusion, continuous infusion produced a similar effect compared to rapid infusion with mannitol diuresis and maximum effect was observed in continuous infusion with concomitant mannitol diuresis.
为评估持续输注对大剂量顺铂（CDDP）肾毒性的预防作用，我们在以不同给药方式给予这种抗肿瘤药物的家兔中监测了肾功能。肾皮质切片的131I-马尿酸摄取、组织病理学检查以及血清肌酐和尿素氮水平被用作评估肾损伤的参数。当以3mg/kg的剂量给予CDDP时，持续输注在降低肾毒性方面显示出与快速输注联合甘露醇利尿相似的效果。对于6mg/kg的大剂量，只有持续输注与甘露醇利尿联合使用才能显著降低肾毒性。当以3mg/kg的CDDP每周连续给药1次，共给药5周时，与快速输注联合甘露醇利尿相比，持续输注产生了相似甚至更有益的效果，并且在持续输注联合甘露醇利尿时观察到最大效果。总之，与快速输注联合甘露醇利尿相比，持续输注产生了相似的效果，并且在持续输注联合甘露醇利尿时观察到最大效果。
