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在使用全身性糖皮质激素进行过渡后，用氨苯砜治疗重症婴儿大疱性类天疱疮。

Severe Infantile Bullous Pemphigoid Treated with Dapsone after Bridging with Systemic Glucocorticoid.

作者信息

Thomsen Kenneth, Deleuran Mette, Vestergaard Christian, Holm Mette, Riber-Hansen Rikke, Bech Rikke

机构信息

Department of Dermatology and Venerology, Aarhus University Hospital, Aarhus, Denmark.

Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Case Rep Dermatol. 2019 Jun 26;11(2):187-193. doi: 10.1159/000501359. eCollection 2019 May-Aug.

DOI:10.1159/000501359
PMID:31320867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6616048/
Abstract

We present a case of severe and treatment-refractory bullous pemphigoid in a 3-month-old child. After topical and systemic corticoid treatment proved inefficient, dapsone 0.75 mg/kg was added initially without success. Disease control was reached with dapsone 1.5 mg/kg in addition to both topical and systemic glucocorticoid treatment, leaving the child with several side effects of the glucocorticoid treatment.

摘要

我们报告了一例3个月大儿童的严重且治疗难治性大疱性类天疱疮。在局部和全身使用皮质类固醇治疗无效后，最初添加了0.75毫克/千克的氨苯砜，但未成功。除局部和全身糖皮质激素治疗外，使用1.5毫克/千克的氨苯砜实现了疾病控制，但该患儿出现了糖皮质激素治疗的多种副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/6616048/1f1c0c7a2fc8/cde-0011-0187-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/6616048/f3e32888737e/cde-0011-0187-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/6616048/1f1c0c7a2fc8/cde-0011-0187-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/6616048/f3e32888737e/cde-0011-0187-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70f/6616048/1f1c0c7a2fc8/cde-0011-0187-g02.jpg

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本文引用的文献

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2
Clarithromycin as a steroid sparing agent for the management of infantile bullous pemphigoid.克拉霉素作为一种用于治疗婴儿大疱性类天疱疮的激素节省剂。
BMJ Case Rep. 2018 Jan 26;2018:bcr-2017-223507. doi: 10.1136/bcr-2017-223507.
3
Infantile bullous pemphigoid successfully treated with intravenous immunoglobulin therapy.
JAAD Case Rep. 2020 Apr 18;6(6):473-475. doi: 10.1016/j.jdcr.2020.04.006. eCollection 2020 Jun.
Clin Exp Dermatol. 2017 Jul;42(5):576-578. doi: 10.1111/ced.13104. Epub 2017 May 22.
4
A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200 mg/day) with that of oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial.一项随机对照试验，比较多西环素（200毫克/天）与口服泼尼松龙（0.5毫克/千克/天）用于大疱性类天疱疮初始治疗的安全性、有效性和成本效益：大疱性类天疱疮类固醇与四环素（BLISTER）试验。
Health Technol Assess. 2017 Mar;21(10):1-90. doi: 10.3310/hta21100.
5
Spectrum of Clinical Responses to Therapies in Infantile Bullous Pemphigoid.
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6
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7
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9
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