唐氏综合征先天性心脏病的性别差异：来自日本某地区医疗记录和问卷调查的研究数据
Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan.
作者信息
Takano Takako, Akagi Michio, Takaki Haruyoshi, Inuzuka Ryo, Nogimori Yoshitsugu, Ono Hiroshi, Kaneko Masahide, Hagiwara Norifumi
机构信息
Department of Child Health, Tokyo Kasei University, Itabashi-ku, Japan.
Department of Medical Education, Kyorin University, Mitaka, Japan.
出版信息
BMJ Paediatr Open. 2019 Jun 26;3(1):e000414. doi: 10.1136/bmjpo-2018-000414. eCollection 2019.
Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals' medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018).
报告显示，在澳大利亚，唐氏综合征（DS）女性患者的存活率低于男性，这与普通人群中女性的长寿情况形成对比。我们利用来自日本五家医院病历以及唐氏综合征患者父母填写的问卷中的1310名唐氏综合征患者（626名女性和684名男性）的数据，调查了可能与死亡率相关的先天性心脏病（CHD）的性别差异。女性的先天性心脏病发病率（354例，57%）显著高于男性（338例，49%；p = 0.010）。接受先天性心脏病手术的女性（199例，32%）明显多于男性（175例，26%；p = 0.018）。
Zotero 插件