Masaki M, Higurashi M, Iijima K, Ishikawa N, Tanaka F, Fujii T, Kuroki Y, Matsui I, Iinuma K, Matsuo N, Takeshita K, Hashimoto S
Am J Hum Genet. 1981 Jul;33(4):629-39.
Mortality and survival data for 1,052 Japanese patients with Down syndrome who were born between 1966 and 1975 were analyzed. The survival rate at age 10 was estimated to be about 86%. Mortality in each age group for Down syndrome was elevated over that of the general population. In the survival rate at age 10, there was no significant difference between males and females, but the difference between cases with and without congenital heart disease was highly significant. Using data from this study-for mortality up to age 10-and from the study of institutionalized cases for mortality over age 10, a hypothetical life table was constructed; it shows that the life expectancy at birth for cases with Down syndrome is nearly 50 years.
对1966年至1975年间出生的1052名日本唐氏综合征患者的死亡率和生存数据进行了分析。10岁时的生存率估计约为86%。唐氏综合征各年龄组的死亡率均高于普通人群。在10岁时的生存率方面，男性和女性之间没有显著差异，但有先天性心脏病和无先天性心脏病的病例之间差异非常显著。利用本研究中10岁以下死亡率的数据以及机构收容病例中10岁以上死亡率的研究数据，构建了一个假设生命表；该表显示，唐氏综合征患者出生时的预期寿命接近50岁。
