来自[植物名称未给出]种子的二萜类化合物及其对蛋白酪氨酸磷酸酶1B的抑制活性和对链脲佐菌素诱导的糖尿病小鼠的降血糖作用。
Diterpenes from seeds of and their PTP1B inhibitory activity and hypoglycemic effects in streptozotocin-induced diabetic mice.
作者信息
Perez Gutierrez Rosa Martha, Baez Efren Garcia
机构信息
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias Extractivas, Instituto Politecnico Nacional (IPN) Unidad Profesional Adolfo Lopez Mateos S/N Av, Instituto Politécnico Nacional Ciudad de Mexico, Mexico City, Mexico.
Laboratory of Supramolecular Chemistry and Nanosciences, Instituto Politecnico Nacional, Acueducto s/n, Barrio la Laguna Ticoman, Mexico City, Mexico.
出版信息
J Asian Nat Prod Res. 2020 Jul;22(7):603-617. doi: 10.1080/10286020.2019.1636786. Epub 2019 Jul 19.
This present study was to evaluate the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of nine diterpenes isolated from seeds of , as well as their effect on streptozotocin-nicotinamide-induced type 2 diabetic mice. Their structures were established by spectroscopic analyses. Diterpenes, 1, and exhibited the strongest inhibitory activity on PTP1B with IC values of 6.9, 7.3, and 6.5 µM, respectively, The administration of showed significant effect on hyperglycemia, among them and reduced fasting glucose levels (55.65%, 54.27%, and 51.22%, respectively). Results revealed that diterpenes performed potential antidiabetic activity via inhibition of PTP1B.[Formula: see text].
本研究旨在评估从[植物名称]种子中分离出的9种二萜类化合物对蛋白酪氨酸磷酸酶1B（PTP1B）的抑制活性，以及它们对链脲佐菌素-烟酰胺诱导的2型糖尿病小鼠的影响。通过光谱分析确定了它们的结构。二萜类化合物1、[化合物名称1]和[化合物名称2]对PTP1B表现出最强的抑制活性，IC50值分别为6.9、7.3和6.5μM。给予[化合物名称3]对高血糖有显著影响，其中[化合物名称4]和[化合物名称5]降低了空腹血糖水平（分别为55.65%、54.27%和51.22%）。结果表明，二萜类化合物通过抑制PTP1B发挥潜在的抗糖尿病活性。[公式：见原文]
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