Neuromuscular Diseases Unit of the Department of Neurology, Tel Aviv Sourasky Medical Center, the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Division of Endocrinology and Metabolism, Department of Medicine, Sinai Health System, and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
Can J Neurol Sci. 2019 Nov;46(6):762-766. doi: 10.1017/cjn.2019.246.
To explore whether higher degrees of electrophysiological abnormalities are associated with a more frequent exposure to a more aggressive treatment regimen, we performed a retrospective chart review of patients attending the neuromuscular clinic from June 2012 to December 2015 and included 87 patients. We compared treatment regimens during the follow-up period between patients with high and low jitter and decrement. Myasthenia gravis patients with high jitter or decrement at baseline were more frequently treated with intravenous immunoglobulins (IVIG) and/or plasma exchange (PLEX) during the follow-up period. In patients with mild disease, IVIG or PLEX treatment was associated with high decrement.
为了探究电生理异常程度较高是否与更频繁地接受侵袭性更强的治疗方案有关，我们对 2012 年 6 月至 2015 年 12 月期间在神经肌肉诊所就诊的 87 例患者进行了回顾性图表审查。我们比较了高 jitter 和低 jitter 以及低 decrement 患者在随访期间的治疗方案。基线时 jitter 或 decrement 较高的重症肌无力患者在随访期间更常接受静脉注射免疫球蛋白（IVIG）和/或血浆置换（PLEX）治疗。在病情较轻的患者中，IVIG 或 PLEX 治疗与高 decrement 相关。
