Gotsadze M, Narsia N, Momtselidze N, Mantskava M
1Tbilisi State Medical University; 3St. Lazare Clinic, Tbilisi, Georgia.
1Tbilisi State Medical University.
Georgian Med News. 2019 May(290):59-63.
The goals of this project were to determine how hemodynamics and hemorheological change in patients diagnosed with different forms of atrial fibrillation; also, how relievers of changes in fibrinogen monitoring in patients with permanent, persistent, paroxysmal forms of arrhythmias. There was examined 30 patients (the average age of patients 65). Patients and control groups have been tested the following studies: index of erythrocytes aggregability, deformability, plasma viscosity to evaluate the blood rheological parameter, also -Fibrinogen to determine of coagulation condition. The Index of the Erythrocytes aggregation was done with the system of textural analyzes. These new innovative methods "Georgian Technique" is created by Georgian scientists and they are famous in the world as direct, numeral and exact. The index of the deformation of the erythrocytes was done with filtration method. Plasma viscosity was measured in the capillary viscosimeter in 370 C. According to the obtained data patients with atrial fibrillation have the same conditions of rheological and coagulation systems, despite of the forms of the atrial fibrillation. And it is different compared to the control group. In the statistical processing of the total row of fibrinogen, the patients were divided into 3 categories. As it turned out fibrinogen and Index of erythrocytes aggregation are in a linear relationship. The quantity of fibrinogen and of erythrocytes aggregation increase simultaneously and the greater the sequential number of the category is, the changes are more pronounced. However, the change/variability of each biological parameter, as shown from our data, is not uniform and linear. The obtained results clearly illustrate the existence of two parallel mechanisms in the body. These are on the one hand the systems of coagulation, anti-coagulation and fibtinollysis. These processes are in a state of the weighted condition, and they are characterized by dynamic equilibrium. On the other hand, the rheology system, which involves the combination of blood flow, blood velocity, vascular stiffness / elasticity, is characterized by one direction going on, with the adequacy and non-existing antipodal mechanisms. The hemorheological system does not have a physiologically balanced opposing anti-rheological system. All of this generate that the hemorheological status is very important in the development and formation of some disease. The arrangement of a rheologycal system is taking preventive character. On the one hand, the rheologycal system is a consolidation of diagnosis and evaluation of the mechanisms. Also, it is the treatment target. Normalization of them is very important in the therapeutic standpoint of the individual.
本项目的目标是确定被诊断为不同类型心房颤动的患者的血流动力学和血液流变学如何变化；此外，还要确定在永久性、持续性、阵发性心律失常患者中，纤维蛋白原监测变化的缓解因素。研究了30名患者（患者平均年龄65岁）。对患者组和对照组进行了以下研究：红细胞聚集性指数、变形性、血浆粘度以评估血液流变学参数，以及纤维蛋白原以确定凝血状况。红细胞聚集指数采用纹理分析系统进行测定。这些新的创新方法“格鲁吉亚技术”由格鲁吉亚科学家创造，在世界上以直接、数字化和精确而闻名。红细胞变形指数采用过滤法进行测定。血浆粘度在37℃的毛细管粘度计中测量。根据获得的数据，心房颤动患者的流变学和凝血系统状况相同，无论心房颤动的类型如何。与对照组相比存在差异。在对纤维蛋白原总行数进行统计处理时，将患者分为3类。结果表明，纤维蛋白原与红细胞聚集指数呈线性关系。纤维蛋白原数量和红细胞聚集同时增加，类别序号越大，变化越明显。然而，根据我们的数据，每个生物学参数的变化/变异性并不均匀和呈线性。获得的结果清楚地说明了体内存在两种平行机制。一方面是凝血、抗凝和纤维蛋白溶解系统。这些过程处于加权状态，其特征是动态平衡。另一方面，流变学系统涉及血流、血流速度、血管硬度/弹性的组合，其特征是单向进行，具有充分性且不存在相反机制。血液流变学系统没有生理上平衡的对抗性抗流变系统。所有这些都表明血液流变学状态在某些疾病的发生和形成中非常重要。流变学系统的安排具有预防性质。一方面，流变学系统是对机制的诊断和评估的巩固。它也是治疗目标。从个体治疗角度来看，使其正常化非常重要。
