Astashina N B, Plyukhin D V, Sosnin D Yu, Mudrova O A
E.A. Vagner Perm State Medical University, Perm, Russia.
South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
Stomatologiia (Mosk). 2019;98(3):31-34. doi: 10.17116/stomat20199803131.
The aim of the study was to elucidate of changes in the level of lipid peroxidation products in saliva for the development of a method for the early diagnosis of complications in dental implantation. The study included 53 patients with complications of implant treatment, 31 patients with a safe outcome of dental implantation, and 13 clinically healthy individuals. In the saliva obtained at the stage of preparation for dental implantation, the content of products of lipid peroxidation was determined. Re-saliva was taken four months after dental implantation or in the case of peri-implantitis verification. It is established that the development of inflammatory complications of dental implantation is accompanied by the development of oxidative stress, which leads to local accumulation of lipoperoxidation products. An increase in the salivary level of products of lipid peroxidation during dental implantation is observed before the formation of clinically significant changes in the tissues of the implantation canal and is associated with a high risk of development of inflammatory complications of dental implantation. The most informative and prognostically unfavorable is the increase in the salivar level of the Schiff bases.
本研究的目的是阐明唾液中脂质过氧化产物水平的变化，以开发一种早期诊断牙种植并发症的方法。该研究纳入了53例种植治疗出现并发症的患者、31例牙种植结局安全的患者以及13名临床健康个体。在牙种植准备阶段采集的唾液中，测定脂质过氧化产物的含量。在牙种植后四个月或进行种植体周围炎核查时再次采集唾液。已证实牙种植炎症并发症的发生伴随着氧化应激的发展，这会导致脂质过氧化产物的局部积累。在种植管组织出现临床显著变化之前，观察到牙种植过程中唾液脂质过氧化产物水平升高，且这与牙种植炎症并发症发生的高风险相关。最具信息价值且预后不利的是席夫碱唾液水平的升高。
