Heidarianpour Ali, Shokri Elnaz, Baghian Tayebe, Shokri Behnaz
Associate Professor of Exercise Physiology, Bu Ali Sina University, Faculty of Sport Sciences, Hamedan, Iran, Phone: +9838381422.
Department of Exercise Physiology, Bu Ali Sina University, Faculty of Sport Sciences, Hamedan, Iran.
J Pediatr Endocrinol Metab. 2019 Sep 25;32(9):1005-1011. doi: 10.1515/jpem-2018-0484.
Background The aim of this study was to investigate the effect of 12 weeks of aerobic training, 4 weeks of detraining and use gonadotropin-releasing hormone agonist (GnRHa) on serum C-reactive protein (CRP) and cortisol levels in girls with central precocious puberty (CPP). Methods Forty-five girls (aged 6-8 years) with precocious puberty were randomly divided into three groups (medication, training and medicine + training groups). Fifteen healthy girls (without precocious puberty) were also included as the control group. Serum CRP and cortisol levels were measured at baseline by the enzyme-linked immunosorbent assay (ELISA) technique. Then, the experimental groups performed an aerobic training program for 3 days/week 20-75 min per day at 45-75% maximum heart rate for 12 weeks. The medication groups also received GnRHa during the study, once a month (1 mL every 4 weeks) by intramuscular injection. Serum CRP and cortisol levels were measured again 48 h after the last training session and also after 4 weeks of detraining. Results Analysis of variance (ANOVA) with repeated measures showed a significant decrease in CRP (p = 0.02) and cortisol levels (p = 0.01) in the training group and the medicine + training group. Detraining led to return of CRP and cortisol levels to the pre-training levels (p = 0.001). No significant difference in serum CRP (p = 0.43) and cortisol levels (p = 0.06) was observed in the medication group. Further, no significant difference was observed between groups in CRP and cortisol. Conclusions Long-term regular moderate training decreases inflammation indices, and detraining eliminates the benefits of training in girls with precocious puberty.
背景 本研究旨在探讨12周有氧运动训练、4周停训以及使用促性腺激素释放激素激动剂（GnRHa）对中枢性性早熟（CPP）女童血清C反应蛋白（CRP）和皮质醇水平的影响。方法 将45名性早熟女童（年龄6 - 8岁）随机分为三组（药物治疗组、训练组和药物 + 训练组）。还纳入了15名健康女童（无性早熟）作为对照组。采用酶联免疫吸附测定（ELISA）技术在基线时测量血清CRP和皮质醇水平。然后，实验组每周进行3天有氧运动训练，每天20 - 75分钟，运动强度为最大心率的45 - 75%，持续12周。药物治疗组在研究期间还每月接受一次GnRHa，通过肌肉注射给药（每4周1 mL）。在最后一次训练 session 后48小时以及停训4周后再次测量血清CRP和皮质醇水平。结果 重复测量方差分析（ANOVA）显示，训练组和药物 + 训练组的CRP（p = 0.02）和皮质醇水平（p = 0.01）显著降低。停训导致CRP和皮质醇水平恢复到训练前水平（p = 0.001）。药物治疗组的血清CRP（p = 0.43）和皮质醇水平（p = 0.06）无显著差异。此外，各组之间的CRP和皮质醇无显著差异。结论 长期规律的适度训练可降低炎症指标，而停训会消除性早熟女童训练带来的益处。
