运动和停训对性早熟女童青春期征象和部分炎症标志物的影响。

Effect of Exercise and Detraining on Signs of Puberty and Selected Inflammatory Markers in Girls with Precocious Puberty.

机构信息

Faculty of Sports Sciences, Bu-Ali Sina University, Hamedan, IRAN.

出版信息

Med Sci Sports Exerc. 2023 Jul 1;55(7):1133-1142. doi: 10.1249/MSS.0000000000003138. Epub 2023 Feb 9.

DOI:10.1249/MSS.0000000000003138

PMID:36790953

Abstract

PURPOSE

We examined the effects of aerobic exercise and detraining on adiponectin, resistin, tumor necrosis factor alpha (TNF-α), white blood cell, and pubertal signs (uterine length, ovarian volume, luteinizing hormone [LH], and follicle-stimulating hormone [FSH]) in girls with central precocious puberty (CPP).

METHODS

Thirty girls with CPP (7-9 yr old) were randomly divided into CPP and CPP + Exercise (EX) groups. Fifteen healthy age-matched girls without precocious puberty participated for comparison with CPP. Subjects in the CPP + EX group attended 12 wk of aerobic exercise protocol three sessions a week. In the baseline, after completing the exercise protocol and after 4 wk of detraining, all the parameters were measured. In the CPP and healthy groups, all the parameters were measured in all three stages. To measure adiponectin, resistin, and TNF-α, the ELISA method was used. LH and FSH were measured by electrochemiluminescence immunoassay. White blood cell counts were analyzed by an automated blood cell counter. Repeated-measures ANOVA was used to analyze the results.

RESULTS

CPP girls have lower adiponectin ( P = 0.01) and higher TNF-α levels ( P = 0.001) than healthy girls. In the CPP + EX group, after 12 wk, body weight and fat mass decreased, and adiponectin increased significantly ( P = 0.02). Resistin ( P = 0.02), TNF-α ( P = 0.02), neutrophils ( P = 0.01), and signs of puberty significantly ( P < 0.05) decreased. After detraining, no significant change was observed except TNF-α, which increased significantly ( P = 0.03). In the CPP group, no significant change was observed in any of the parameters; only LH ( P = 0.0001) and uterine length and ovarian volume ( P = 0.003, P = 0.001) decreased after 12 and 16 wk, respectively.

CONCLUSIONS

Aerobic exercise can have a positive effect on the state of inflammation and pubertal signs. Positive effects remain after 4 wk of detraining.

摘要

目的

研究有氧运动和停训对中枢性性早熟（CPP）女孩脂联素、抵抗素、肿瘤坏死因子-α（TNF-α）、白细胞和青春期征象（子宫长度、卵巢体积、黄体生成素[LH]和卵泡刺激素[FSH]）的影响。

方法

将 30 名 CPP 女孩（7-9 岁）随机分为 CPP 组和 CPP+运动（EX）组。15 名健康无性早熟的同龄女孩参与与 CPP 组比较。CPP+EX 组的受试者每周参加 3 次、为期 12 周的有氧运动方案。在基线时、完成运动方案后和停训 4 周后，测量所有参数。在 CPP 和健康组中，所有参数均在三个阶段进行测量。采用 ELISA 法测量脂联素、抵抗素和 TNF-α。采用电化学发光免疫分析法测量 LH 和 FSH。采用自动血细胞计数器分析白细胞计数。采用重复测量方差分析分析结果。

结果

CPP 女孩的脂联素水平较低（P=0.01），TNF-α水平较高（P=0.001），与健康女孩相比。在 CPP+EX 组中，12 周后，体重和体脂减少，脂联素显著增加（P=0.02）。抵抗素（P=0.02）、TNF-α（P=0.02）、中性粒细胞（P=0.01）和青春期征象显著（P<0.05）下降。停训后，除 TNF-α显著增加（P=0.03）外，其他指标无明显变化。CPP 组中，除 12 和 16 周后 LH（P=0.0001）和子宫长度和卵巢体积（P=0.003，P=0.001）分别下降外，其他参数均无明显变化。