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[古替明对完整神经元中黄素和吡啶核苷酸氧化还原状态的作用]

[Action of gutimine on the redox status of flavin and pyridine nucleotides in intact neurons].

作者信息

Ianvareva I N, Il'chenko I D, Burgova M P, Vinogradov V M

出版信息

Farmakol Toksikol. 1988 Mar-Apr;51(2):47-50.

PMID:3132401
Abstract

Redox-reactions of flavine (FN) and pyridine (PN) nucleotides of the cell to guthimine were studied by the method of fluorescent microscopy without using any stains. The comparison was made of the kinetics of fluorescence intensity of FN and PN of the Retzius intact neuron under the action of guthimine, oxaloacetate, nembutal and succinate. It is suggested that guthimine may activate the switching of oxidative metabolism of the cell over to a more energitically profitable way.

摘要

采用荧光显微镜法,在不使用任何染色剂的情况下,研究了细胞中黄素(FN)和吡啶(PN)核苷酸与谷硫磷的氧化还原反应。比较了在谷硫磷、草酰乙酸、戊巴比妥和琥珀酸作用下,雷丘斯完整神经元中FN和PN荧光强度的动力学。研究表明,谷硫磷可能会激活细胞的氧化代谢转换为一种能量利用更高效的方式。

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