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B 细胞易位基因 1 在子宫内膜异位症发病机制中的作用。

Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis.

机构信息

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan 44033, Korea.

Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

出版信息

Int J Mol Sci. 2019 Jul 9;20(13):3372. doi: 10.3390/ijms20133372.

DOI:10.3390/ijms20133372
PMID:31324015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6651142/
Abstract

Estrogen affects endometrial cellular proliferation by regulating the expression of the gene. B-cell translocation gene 1 (BTG1), a translocation partner of the , is a tumor suppressor gene that promotes apoptosis and negatively regulates cellular proliferation and cell-to-cell adhesion. The aim of this study was to determine the role of BTG1 in the pathogenesis of endometriosis. mRNA and protein expression was evaluated in eutopic and ectopic endometrium of 30 patients with endometriosis (endometriosis group), and in eutopic endometrium of 22 patients without endometriosis (control group). The effect of BTG1 downregulation on cellular migration, proliferation, and apoptosis was evaluated using transfection of primarily cultured human endometrial stromal cells (HESCs) with siRNA. mRNA expression level of eutopic and ectopic endometrium of endometriosis group were significantly lower than that of the eutopic endometrium of the control group. Migration and wound healing assays revealed that BTG1 downregulation resulted in a significant increase in migration potential of HESCs, characterized by increased expression of matrix metalloproteinase 2 (MMP2) and MMP9. Downregulation of BTG1 in HESCs significantly reduced Caspase 3 expression, indicating a decrease in apoptotic potential. In conclusion, our data suggest that downregulation of BTG1 plays an important role in the pathogenesis of endometriosis.

摘要

雌激素通过调节 基因的表达影响子宫内膜细胞的增殖。B 细胞易位基因 1（BTG1）是一种易位伙伴，是一种肿瘤抑制基因，可促进细胞凋亡并负调控细胞增殖和细胞间黏附。本研究旨在探讨 BTG1 在子宫内膜异位症发病机制中的作用。通过对 30 例子宫内膜异位症患者（子宫内膜异位症组）的在位和异位子宫内膜以及 22 例无子宫内膜异位症患者（对照组）的在位子宫内膜进行评估，评估了 BTG1 在其中的表达情况。通过用 siRNA 转染原代培养的人子宫内膜基质细胞（HESCs）来评估 BTG1 下调对细胞迁移、增殖和凋亡的影响。与对照组相比，子宫内膜异位症组的在位和异位子宫内膜的 mRNA 表达水平显著降低。迁移和伤口愈合试验表明，BTG1 下调导致 HESCs 的迁移潜能显著增加，其特征是基质金属蛋白酶 2（MMP2）和 MMP9 的表达增加。BTG1 在 HESCs 中的下调显著降低了 Caspase 3 的表达，表明凋亡潜能降低。总之，我们的数据表明 BTG1 的下调在子宫内膜异位症的发病机制中起着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/519b34553250/ijms-20-03372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/9d021f5e08fa/ijms-20-03372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/e6a1b605cd07/ijms-20-03372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/871d8b1a5558/ijms-20-03372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/69a61a3cf79c/ijms-20-03372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/519b34553250/ijms-20-03372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/9d021f5e08fa/ijms-20-03372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/e6a1b605cd07/ijms-20-03372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/871d8b1a5558/ijms-20-03372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/69a61a3cf79c/ijms-20-03372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be67/6651142/519b34553250/ijms-20-03372-g005.jpg

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本文引用的文献

1
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2
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J Cancer. 2017 Aug 22;8(14):2669-2675. doi: 10.7150/jca.21037. eCollection 2017.
3
Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis.
子宫非典型中肾样增生具有克氏大鼠肉瘤病毒癌基因同源物 () 的致病性突变和 1q 染色体获得。
Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):813-826. doi: 10.21873/cgp.20235.
4
Targeted Genomic Sequencing Reveals Different Evolutionary Patterns Between Locally and Distally Recurrent Glioblastomas.靶向基因组测序揭示局部和远处复发性胶质母细胞瘤的不同进化模式。
Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):803-812. doi: 10.21873/cgp.20234.
芳香化酶抑制剂调节子宫内膜异位症女性子宫内膜细胞中let-7的表达及let-7f诱导的细胞迁移。
Fertil Steril. 2016 Sep 1;106(3):673-80. doi: 10.1016/j.fertnstert.2016.05.020. Epub 2016 Jun 16.
4
Correlation Between the Clinical Parameters and Tissue Phenotype in Patients Affected by Deep-Infiltrating Endometriosis.深部浸润型子宫内膜异位症患者临床参数与组织表型的相关性
Reprod Sci. 2016 Sep;23(9):1258-68. doi: 10.1177/1933719116638188. Epub 2016 Mar 18.
5
Correlation between matrix metalloproteinase-9 and endometriosis.基质金属蛋白酶-9与子宫内膜异位症之间的相关性。
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