肺血管灌注不足评分在支气管肺发育不良合并肺动脉高压早产儿中的应用。

Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare, Hollywood, FL 33021, USA.

Medicina (Kaunas). 2019 Jul 9;55(7):359. doi: 10.3390/medicina55070359.

Pulmonary hypertension (PH) is a complication of bronchopulmonary dysplasia (BPD). The underlying pathophysiology of BPD-associated PH is complex and poorly understood. Echocardiogram may underestimate the severity of pulmonary hypertensive vascular disease in severe BPD. Digital subtraction pulmonary angiography (DSPA) is a potentially useful imaging modality for evaluating changes in the pulmonary vasculature of BPD-associated PH. In this study, we objectively quantified the pulmonary hypertensive vascular changes demonstrated by DSPA using a novel pulmonary vascular underperfusion score (PVUS) and correlated the scoring system with echocardiography parameters and cardiac hemodynamics by right heart catheterization.

肺动脉高压（PH）是支气管肺发育不良（BPD）的并发症。BPD 相关 PH 的潜在病理生理学非常复杂，目前尚未完全了解。超声心动图可能会低估严重 BPD 中肺动脉高压性血管疾病的严重程度。数字减影肺动脉造影（DSPA）是一种评估 BPD 相关 PH 肺血管病变变化的潜在有用成像方式。在这项研究中，我们使用一种新的肺血管灌注不足评分（PVUS）客观量化了 DSPA 显示的肺动脉高压性血管变化，并通过右心导管检查将评分系统与超声心动图参数和心脏血流动力学相关联。