Rodamilans M, Osaba M J, To-Figueras J, Rivera Fillat F, Marques J M, Pérez P, Corbella J
Laboratorio Hormonal, Hospital Clínic i Provincial, Facultad de Medicina, Universidad de Barcelona, Spain.
Hum Toxicol. 1988 Mar;7(2):125-8. doi: 10.1177/096032718800700203.
The hypothalamo-pituitary-testicular axis was evaluated in a group of 23 men who worked in the lead smelting industry and had a history of occupational inorganic lead exposure. The endocrine status of the workers was related to lead poisoning biological markers. According to the duration of their lead exposure they were divided into three groups: group 1 less than 1 year, n = 5; group 2 between 3 and 5 years, n = 8; group 3 greater than 5 years, n = 10. Serum testosterone (T), steroid binding globulin (SBG), free testosterone index (T/SBG), serum luteinizing hormone (LH), follicle stimulating hormone (FSH), Blood lead levels, and blood zinc protoporphyrin (ZPP) were measured in all workers. Groups 2 and 3 showed a decrease in serum testosterone levels, an increase in SBG levels, and a decrease in T/SBG index, suggesting a correlation between testicular dysfunction and duration of exposure. There was an increase in serum LH in group 1, which was not progressive. This suggests that prolonged lead exposure initially produces a direct testicular toxicity followed by hypothalamic or pituitary disturbance when longer periods of exposure take place.
对一组23名在铅冶炼行业工作且有职业性无机铅接触史的男性进行了下丘脑 - 垂体 - 睾丸轴评估。工人的内分泌状况与铅中毒生物标志物相关。根据他们的铅接触持续时间，将他们分为三组：第1组接触时间少于1年，n = 5；第2组接触时间在3至5年之间，n = 8；第3组接触时间超过5年，n = 10。对所有工人测量了血清睾酮（T）、类固醇结合球蛋白（SBG）、游离睾酮指数（T/SBG）、血清促黄体生成素（LH）、卵泡刺激素（FSH）、血铅水平和血锌原卟啉（ZPP）。第2组和第3组显示血清睾酮水平降低、SBG水平升高以及T/SBG指数降低，表明睾丸功能障碍与接触持续时间之间存在相关性。第1组血清LH升高，但不呈进行性。这表明长期铅接触最初产生直接的睾丸毒性，而在接触时间更长时随后会出现下丘脑或垂体紊乱。
