酸性禁食：酸性 pH 值下结核分枝杆菌代谢的调控。
Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH.
机构信息
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Trends Microbiol. 2019 Nov;27(11):942-953. doi: 10.1016/j.tim.2019.06.005. Epub 2019 Jul 16.
Abstract
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic pH that results in the slowing of bacterial growth and changes in redox homeostasis. It is proposed that induction of the PhoPR regulon and anaplerotic metabolism, in concert with the restricted use of specific carbon sources, functions to counter reductive stress associated with acidic pH.
摘要
结核分枝杆菌（Mtb）在发病过程中感知并适应酸性宿主环境。在巨噬细胞或动物感染过程中，酸性 pH 依赖性适应缺陷突变体通常会减弱，这支持这些途径对于发病机制至关重要，并代表了药物发现的重要新靶点。本综述检查了一系列支持结核分枝杆菌在酸性 pH 下限制代谢的发现，这导致细菌生长减缓并改变氧化还原稳态。据推测， PhoPR 调控子和补料代谢的诱导，以及特定碳源的限制使用，共同起到了对抗酸性 pH 相关还原应激的作用。
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