α-肾上腺素能受体拮抗对猫异氟烷最低肺泡浓度的影响。
Effect of α-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane in cats.
作者信息
Pypendop Bruno H, Ahokoivu Hanna, Honkavaara Juhana
机构信息
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
出版信息
Vet Anaesth Analg. 2019 Sep;46(5):658-661. doi: 10.1016/j.vaa.2019.05.002. Epub 2019 Jun 8.
OBJECTIVE
To characterize the effect of α-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane (MAC) in cats.
STUDY DESIGN
Prospective experimental study.
ANIMALS
A group of five healthy adult male neutered cats.
METHODS
Cats were anesthetized with isoflurane in oxygen and instrumented. MAC was determined in duplicate in five cats, before and during administration of atipamezole (250 μg kg followed by 250 μg kg hour) using the bracketing technique and tail clamping. Estimates of MAC obtained before and during administration of atipamezole were compared using a two-tailed paired t test.
RESULTS
MAC during atipamezole administration (mean ± standard deviation 2.73% ± 0.07%) was significantly larger than before atipamezole administration (1.95% ± 0.13%; p < 0.0001).
CONCLUSION AND CLINICAL RELEVANCE
The role of α-adrenoceptors in inhaled anesthetic-induced immobility may be larger than previously thought. Antagonism of an α-adrenoceptor agonist during inhalation anesthesia may result in an increase in MAC disproportionate to the MAC reduction induced by the agonist.
目的
研究α-肾上腺素能受体拮抗作用对猫异氟烷最低肺泡有效浓度（MAC）的影响。
研究设计
前瞻性实验研究。
动物
一组五只健康成年雄性去势猫。
方法
猫用异氟烷和氧气麻醉并进行仪器监测。采用夹尾法和括弧法，在五只猫中重复测定MAC，一次在给予阿替美唑（250μg/kg，随后250μg/kg·小时）之前，一次在给药期间。使用双侧配对t检验比较阿替美唑给药前和给药期间获得的MAC估计值。
结果
阿替美唑给药期间的MAC（均值±标准差2.73%±0.07%）显著高于给药前（1.95%±0.13%；p<0.0001）。
结论及临床意义
α-肾上腺素能受体在吸入麻醉诱导的制动中的作用可能比之前认为的更大。吸入麻醉期间α-肾上腺素能受体激动剂的拮抗作用可能导致MAC增加，且增加幅度与激动剂诱导的MAC降低不成比例。
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