Theilen H J, Gerber J C
Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Carl-Gustav-Carus, Fetscherstr. 74, 01307, Dresden, Deutschland.
Institut und Poliklinik für Neuroradiologie, Universitätsklinikum Carl-Gustav-Carus, Fetscherstr. 74, 01307, Dresden, Deutschland.
Anaesthesist. 2019 Nov;68(11):733-741. doi: 10.1007/s00101-019-0621-z.
Early recanalization of the closed cerebral arteries after acute ischemic stroke (AIS) is the only treatment to minimize long-term disability and to reduce the associated morbidity and mortality. For a long time the only proven causal treatment of AIS was intravenous thrombolysis; however, after the publication of a series of randomized prospective studies concerning endovascular mechanical thrombectomy using stent retriever systems after AIS, new guidelines were published. It was found that endovascular treatment (EVT) dramatically improves the outcome of eligible patients. The stent retriever enables high recanalization rates by clot removal from the cerebral arterial system by means of aspiration of the thrombus via the catheter and/or by entrapping it with a stent system. The management of anesthesia during the procedure is indispensable to prevent hypoxia and hemodynamic instability; however, which form of anesthesia (i.e. general anesthesia vs. conscious sedation) is advantageous for the patient during EVT is controversially discussed. In the first studies using retrospective data conscious sedation resulted in a better outcome compared to general anesthesia following EVT; however, in prospective studies this finding could not be confirmed. To obtain optimal neurological results after AIS and EVT with general anesthesia, it is of tremendous importance not to delay the EVT due to the anesthesiology procedure. Furthermore, hypotension, hypovolemia and hypocapnia should also be strictly avoided. Finally, the optimal anesthesiological approach should be guided by the current clinical state and pre-existing comorbidities of the patient.
急性缺血性卒中(AIS)后闭塞脑动脉的早期再通是将长期残疾降至最低并降低相关发病率和死亡率的唯一治疗方法。长期以来,唯一经证实的AIS因果治疗方法是静脉溶栓;然而,在一系列关于AIS后使用支架取栓系统进行血管内机械取栓的随机前瞻性研究发表后,新的指南发布了。研究发现,血管内治疗(EVT)显著改善了符合条件患者的预后。支架取栓器通过经导管抽吸血栓和/或用支架系统捕获血栓,从脑动脉系统中清除血栓,从而实现高再通率。手术过程中的麻醉管理对于预防缺氧和血流动力学不稳定是必不可少的;然而,在EVT期间哪种麻醉方式(即全身麻醉与清醒镇静)对患者更有利,目前仍存在争议。在最初使用回顾性数据的研究中,与EVT后的全身麻醉相比,清醒镇静的结果更好;然而,在前瞻性研究中,这一发现未能得到证实。为了在全身麻醉下进行AIS和EVT后获得最佳神经学结果,至关重要的是不要因麻醉程序而延迟EVT。此外,还应严格避免低血压、低血容量和低碳酸血症。最后,最佳的麻醉方法应以患者当前的临床状态和既往合并症为指导。