Keele University, Keele, Staffordshire, UK, and La Trobe University, Melbourne, Victoria, Australia.
Keele University, Keele, Staffordshire, UK.
Arthritis Care Res (Hoboken). 2020 Oct;72(10):1343-1348. doi: 10.1002/acr.24030.
To examine associations between calcaneal enthesophytes and osteoarthritis (OA) in the hands and feet, and to provide insights into the role of biomechanical and systemic processes in the development of OA.
Adults ages ≥50 years who were registered with 4 general practices were mailed a Health Survey. Responders reporting foot pain within the last 12 months underwent a detailed assessment, including hand and foot radiographs. Calcaneal enthesophytes (plantar and posterior) and OA features (osteophytes and joint space narrowing) were documented. Associations between enthesophytes and hand and foot OA (including OA phenotypes and OA features at individual joints) were explored using generalized estimating equations, adjusting for age, sex, and body mass index.
Data were available from 532 participants (298 women, mean ± SD age 64.9 ± 8.4 years). Calcaneal enthesophytes were not associated with hand OA phenotypes or OA at individual hand joints. In contrast, plantar calcaneal enthesophytes were positively associated with polyarticular foot OA (odds ratio [OR] 1.80 [95% confidence interval (95% CI) 1.02-3.17]). When individual foot joints were examined, posterior enthesophytes were associated with talonavicular joint OA (OR 1.58 [95% CI 1.02-2.44]) and plantar enthesophytes were associated with first metatarsophalangeal joint OA (OR 0.67 [95% CI 0.49-0.98]) and navicular-cuneiform joint OA (OR 2.30 [95% CI 1.40-3.79]). Patterns of association were similar for osteophytes and joint space narrowing.
Calcaneal enthesophytes are associated with foot OA but not hand OA. The pattern of association is indicative of a local, biomechanical rather than systemic bone-forming process.
探讨跟骨骨赘与手、足骨关节炎（OA）之间的关联，并深入了解生物力学和全身过程在 OA 发展中的作用。
对参加 4 家普通诊所的年龄≥50 岁的成年人邮寄健康调查问卷。在过去 12 个月内报告足部疼痛的应答者接受详细评估，包括手部和足部 X 线摄影。记录跟骨骨赘（足底和后）和 OA 特征（骨赘和关节间隙变窄）。使用广义估计方程，根据年龄、性别和体重指数调整，探讨骨赘与手和足 OA（包括 OA 表型和各关节 OA 特征）之间的关联。
532 名参与者（298 名女性，平均年龄 64.9 ± 8.4 岁）的数据可用。跟骨骨赘与手 OA 表型或各手关节 OA 无关。相比之下，足底跟骨骨赘与多关节足 OA 呈正相关（比值比 [OR] 1.80 [95%置信区间（95%CI）1.02-3.17]）。当检查各足关节时，后骨赘与跟骰关节 OA 相关（OR 1.58 [95%CI 1.02-2.44]），而足底骨赘与第一跖趾关节 OA 相关（OR 0.67 [95%CI 0.49-0.98]）和舟楔关节 OA（OR 2.30 [95%CI 1.40-3.79]）。骨赘和关节间隙变窄的关联模式相似。
跟骨骨赘与足 OA 相关，但与手 OA 无关。关联模式表明是局部的、生物力学的，而不是全身性的成骨过程。
