Kurata Tsutomu, Hashimoto Tasuku, Suzuki Hitoshi
Department of Psychiatry, Sodegaura Satsukidai Hospital, Sodegaura, Japan.
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan.
Neuropsychopharmacol Rep. 2019 Sep;39(3):238-240. doi: 10.1002/npr2.12072. Epub 2019 Jul 20.
Alcohol dependence is frequently comorbid with bipolar I disorder. Aripiprazole and its long-acting injection have demonstrated efficacy in the treatment and prevention of bipolar I disorder and its attendant symptoms, especially manic episodes. However, whether aripiprazole can alleviate alcohol dependence remains controversial. We report the case of a 47-year-old woman who had been diagnosed with bipolar I disorder and alcohol dependence, characterized by poor adherence to pharmacological treatment and our hospital's alcoholic treatment program. Consequently, she was repeatedly hospitalized several times per year due to manic episodes and heavy drinking. After treatment with aripiprazole long-acting injection at a dosage of 400 mg/mo intramuscularly, she has been relapse-free for over 2 years. Aripiprazole long-acting injection might therefore be effective for treating patients with bipolar disorder and a comorbid diagnosis of alcohol dependence.
酒精依赖常与双相I型障碍共病。阿立哌唑及其长效注射剂已证明在双相I型障碍及其伴随症状（尤其是躁狂发作）的治疗和预防中有效。然而，阿立哌唑是否能缓解酒精依赖仍存在争议。我们报告了一例47岁女性病例，她被诊断为双相I型障碍和酒精依赖，其特点是对药物治疗和我院酒精治疗项目依从性差。因此，她每年因躁狂发作和大量饮酒而多次反复住院。在以每月400mg的剂量肌肉注射阿立哌唑长效注射剂治疗后，她已超过2年无复发。因此，阿立哌唑长效注射剂可能对治疗双相情感障碍合并酒精依赖诊断的患者有效。
