Tamaki N, Fujimoto S, Mizota C, Kikugawa M
Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1987 Dec;33(6):439-49. doi: 10.3177/jnsv.33.439.
beta-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while beta-ureidopropionase, the last one of uracil-metabolizing enzymes to beta-alanine, was predominantly distributed in the cytosolic fraction. When rat liver mitochondria were separated into submitochondrial fractions, beta-alanine-oxoglutarate aminotransferase was localized in the mitochondrial matrix. beta-Alanine was transported into mitochondria with time and the influx of beta-alanine into the matrix was 0.47 nmol/mg of mitochondrial protein at 2 min after incubation.
大鼠肝脏中的β-丙氨酸-α-酮戊二酸转氨酶主要分布在线粒体部分，而β-脲基丙酸酶作为尿嘧啶代谢生成β-丙氨酸的最后一种酶，主要分布在胞质部分。当将大鼠肝脏线粒体分离成亚线粒体部分时，β-丙氨酸-α-酮戊二酸转氨酶定位于线粒体基质中。β-丙氨酸随时间进入线粒体，孵育2分钟后，β-丙氨酸进入基质的流入量为0.47 nmol/mg线粒体蛋白。
