Department of Physical Education, Minjiang University, Fuzhou 350108, PR China.
Department of Urology, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine (The People's Hospital of Fujian Province), Fuzhou 350004, PR China.
Life Sci. 2019 Sep 15;233:116666. doi: 10.1016/j.lfs.2019.116666. Epub 2019 Jul 17.
Pirfenidone (PFD) has been used as medication for idiopathic pulmonary fibrosis due to its ability in reducing lung fibrosis. However, the underlying mode of action in renal fibrosis during chronic renal allograft dysfunction (CRAD) requires further investigation. Therefore, the present study was conducted to explore the effects of PFD on renal injury induced by CRAD.
Initially, the CRAD rat model was established, followed by the intragastric administration of PFD to the rats. Urine and blood samples were collected and tested against indicators of renal functions. The renal tissues were microscopically observed to determine the changes in pathological morphology. The anti-inflammatory, anti-fibrotic and anti-oxidant properties of PFD were explored in the setting of CRAD.
The success rate of model establishment was 92.31%, which was reflected by weight loss, appetite loss, faded fur, and retarded reaction, with the symptoms found to exacerbate with time. PFD treatment could improve renal function, ameliorate inflammation and renal fibrosis as well as promote the anti-oxidant ability of renal allograft, indicating its potential role as an effective therapeutic agent for CRAD.
In conclusion, PFD was found to have renoprotective effects on renal injury induced by CRAD, which resulted in the alleviation of inflammation and renal fibrosis, providing novelty for CRAD clinical treatment.
吡非尼酮（PFD）因其能够减少肺纤维化而被用于治疗特发性肺纤维化。然而，慢性肾移植功能障碍（CRAD）期间肾纤维化的潜在作用机制仍需进一步研究。因此，本研究旨在探讨 PFD 对 CRAD 诱导的肾损伤的影响。
首先建立 CRAD 大鼠模型，然后对大鼠进行 PFD 灌胃。收集尿液和血液样本，检测肾功能指标。观察肾组织的病理形态变化。探讨 PFD 在 CRAD 中的抗炎、抗纤维化和抗氧化作用。
模型建立的成功率为 92.31%，表现为体重减轻、食欲减退、毛发褪色和反应迟钝，且症状随时间恶化。PFD 治疗可改善肾功能，减轻炎症和肾纤维化，促进肾移植的抗氧化能力，表明其在治疗 CRAD 方面具有潜在的有效性。
综上所述，PFD 对 CRAD 诱导的肾损伤具有肾保护作用，可减轻炎症和肾纤维化，为 CRAD 的临床治疗提供了新的思路。
