Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Regul Toxicol Pharmacol. 2019 Oct;107:104426. doi: 10.1016/j.yrtph.2019.104426. Epub 2019 Jul 17.
Metal-organic frameworks (MOFs) nanoparticles are a class of porous crystalline materials constructed from the bonding metal ions or clusters linked with organic ligands to form frameworks. MIL-101(Cr), one of the most representative MOFs, is a three-dimensional chromium terephthalate-base porous material consisted of chromium (III)-trimers cross-linked by 1,4-benzene dicarboxylate. The present study focused on determining the safety of MIL-101(Cr) nanoparticle. The acute oral toxicity and 28-day oral toxicity in mice were investigated. An acute oral toxicity test of MIL-101(Cr) nanoparticle for female mice showed that no mortality or any significant change observed at 2000 mg/kg body weight. A dose-dependent 28-day oral toxicity evaluation of MIL-101(Cr) nanoparticle for male and female mice revealed no significant effects on mortality, feed consumption, body weight, organ weight, and behavior. Assessments of hematology, clinical biochemistry, and histopathology revealed no adverse effects in mice treated with MIL-101(Cr) nanoparticle (10-1000 mg/kg). These results suggest that MIL-101(Cr) nanoparticle has no significant acute and subacute toxicity. The no observed adverse effect level of MIL-101(Cr) nanoparticle was defined as at least 1000 mg/kg/day orally for 28 days for male and female mice.
金属有机骨架（MOF）纳米粒子是一类多孔晶体材料，由连接金属离子或簇与有机配体形成的骨架构成。MIL-101（Cr）是最具代表性的 MOF 之一，是一种由三价铬三聚体通过 1,4-苯二甲酸交联形成的三维铬对苯二甲酸盐基多孔材料。本研究旨在确定 MIL-101（Cr）纳米粒子的安全性。对其进行了急性口服毒性和 28 天口服毒性试验。对雌性小鼠进行的 MIL-101（Cr）纳米粒子急性口服毒性试验表明，在 2000mg/kg 体重时没有死亡或任何显著变化。对雄性和雌性小鼠进行的剂量依赖性 28 天口服毒性评估显示，死亡率、饲料消耗、体重、器官重量和行为均无显著影响。对接受 MIL-101（Cr）纳米粒子（10-1000mg/kg）治疗的小鼠进行的血液学、临床生物化学和组织病理学评估未发现不良反应。这些结果表明，MIL-101（Cr）纳米粒子无明显的急性和亚急性毒性。MIL-101（Cr）纳米粒子的未观察到不良效应水平定义为雄性和雌性小鼠口服至少 1000mg/kg/天，连续 28 天。
