Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Viet Nam.
Bone and Muscle Research Group, Ton Duc Thang University, Viet Nam; Centre for Big Data Research in Health, UNSW Sydney, Australia.
Diabetes Res Clin Pract. 2019 Sep;155:107790. doi: 10.1016/j.diabres.2019.107790. Epub 2019 Jul 17.
Trabecular bone score (TBS) is a surrogate indicator of bone microarchitecture. The present study sought to examine the association between type 2 diabetes (T2D) and trabecular bone score (TBS) in adult Vietnamese men and women.
The study was part of the Vietnam Osteoporosis Study, in which 2702 women and 1398 men aged ≥30 years were recruited from the general community in Ho Chi Minh City. HbA levels were measured by the ADAMS™ A HA-8160 (Arkray, Kyoto, Japan), and classified into 3 groups: normal if HbA < 5.7%; pre-diabetes (5.7-6.4%); and diabetes (>6.4%). TBS was evaluated by iNsight Software, version 2.1 (Medimaps, Merignac, France) on lumbar spine BMD scan (Hologic Horizon). Differences in TBS between diabetic status were analyzed by the multivariable regression model with adjustment for age and body mass index.
The prevalence of pre-diabetes and diabetes in men and women was 30.2% and 8.3%, respectively. In women, TBS was lower in pre-diabetes (-0.02; P < 0.001) and diabetes (-0.02; P < 0.001) compared with normal individuals. In men, there was no statistically significant difference in TBS between diabetic status. Moreover, TBS was significantly inversely correlated with HbA levels in women (P = 0.01), but not in men (P = 0.89).
Women, but not men, with type 2 diabetes and pre-diabetes have lower TBS than individuals without diabetes. These data suggest that diabetes and prediabetes are associated with deterioration of bone microarchitecture.
骨小梁评分（TBS）是骨微结构的替代指标。本研究旨在探讨 2 型糖尿病（T2D）与越南成年男女的骨小梁评分（TBS）之间的关系。
该研究是越南骨质疏松症研究的一部分，共招募了来自胡志明市社区的 2702 名女性和 1398 名男性，年龄均≥30 岁。HbA 水平采用 ADAMS™ A HA-8160（Arkray，京都，日本）进行测量，并分为 3 组：HbA<5.7%为正常；5.7-6.4%为糖尿病前期；>6.4%为糖尿病。TBS 通过 iNsight 软件（Medimaps，梅里尼亚克，法国）在腰椎 BMD 扫描（Hologic Horizon）上进行评估。采用多变量回归模型，调整年龄和体重指数后，分析糖尿病状态之间 TBS 的差异。
男性和女性的糖尿病前期和糖尿病患病率分别为 30.2%和 8.3%。在女性中，与正常个体相比，糖尿病前期（-0.02；P<0.001）和糖尿病（-0.02；P<0.001）的 TBS 更低。在男性中，糖尿病状态之间的 TBS 无统计学差异。此外，TBS 与女性的 HbA 水平呈显著负相关（P=0.01），但与男性无相关性（P=0.89）。
与无糖尿病的个体相比，患有 2 型糖尿病和糖尿病前期的女性，其 TBS 更低。这些数据表明，糖尿病和糖尿病前期与骨微结构恶化有关。
