酒精依赖合并慢性病毒感染的神经侵袭和认知障碍：初步研究。
Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation.
机构信息
Research & Development Service, Veterans Affairs Portland Health Care System, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA; Methamphetamine Abuse Research Center, Veterans Affairs Portland Health Care System, Oregon Health & Science University, Portland, OR, USA.
Research & Development Service, Veterans Affairs Portland Health Care System, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
出版信息
J Neuroimmunol. 2019 Oct 15;335:577006. doi: 10.1016/j.jneuroim.2019.577006. Epub 2019 Jul 10.
Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.
侵入中枢神经系统 (CNS) 的病毒会导致神经精神损伤。同样，慢性酒精暴露会引起炎症反应，改变大脑功能。然而，慢性病毒感染和合并酒精使用对神经炎症和行为的影响尚不清楚。我们研究了在感染淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 克隆 13 的小鼠中，大量饮酒对调节炎症反应和认知障碍行为迹象的作用。酒精暴露的 LCMV 感染小鼠外周炎症增加，认知功能受损（表现在新物体识别测试中的表现）。初步研究结果表明，病毒感染时小胶质细胞反应的脑区特异性失调可能导致大量饮酒时的认知障碍。
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