Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China.
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Collaborative Innovation Center for Neurogenetics and Channelopathies, Institute of Neuroscience and The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China.
Int J Neurosci. 2019 Dec;129(12):1183-1188. doi: 10.1080/00207454.2019.1645140. Epub 2019 Aug 15.
To investigate the clinical features of five glial fibrillary acidic protein (GFAP) antibody positive patients with suspected benign tumors and explore its underlying pathogenesis. Overall, 1018 serum and cerebrospinal fluid (CSF) samples were tested by indirect immunofluorescence assay and data from five patients with suspected tumors and positive for GFAP autoantibody in the CSF were analyzed retrospectively. The positive rate of GFAP antibody in the serum and CSF was 3.93% by indirect immunofluorescence assay. Tumors were diagnosed before or after neurologic onset in 5 of 40 patients (12.5%) and no deterioration of the tumors was found during the long-term follow-up. Of the five patients, one patient suffered a thyroid nodule, one patient had a small nodule in the left lung, two patients suffered meningiomas, and one patient had a suspicious eosinophilic granuloma. GFAP autoimmunity may be a paraneoplastic immune response with a low frequency of tumor in Chinese patients with GFAP astrocytopathy.
为了研究 5 例疑似良性肿瘤且胶质纤维酸性蛋白 (GFAP) 抗体阳性患者的临床特征，并探讨其潜在发病机制。采用间接免疫荧光法检测了 1018 份血清和脑脊液 (CSF) 样本，回顾性分析了 CSF 中 GFAP 自身抗体阳性且疑似肿瘤的 5 例患者的数据。间接免疫荧光法检测血清和 CSF 中 GFAP 抗体的阳性率分别为 3.93%。40 例患者中有 5 例（12.5%）在神经症状发生前或发生后诊断出肿瘤，且在长期随访过程中肿瘤无恶化。5 例患者中，1 例患有甲状腺结节，1 例左肺有小结节，2 例患有脑膜瘤，1 例疑似嗜酸性肉芽肿。GFAP 自身免疫可能是一种副肿瘤免疫反应，在中国 GFAP 星形胶质病患者中，肿瘤的发生率较低。
