下颌骨髁突微生物学研究在颞下颌关节骨关节炎进展患者中的应用。
Microbiological investigation of the mandibular condyle in patients with advanced osteoarthritis of the temporomandibular joint.
机构信息
Maxillofacial Surgery Unit, Dept of Surgery, St Vincent's Hospital, University of Melbourne, Victoria, Australia.
Melbourne Dental School, The University of Melbourne, Victoria, Australia.
出版信息
J Craniomaxillofac Surg. 2019 Aug;47(8):1262-1265. doi: 10.1016/j.jcms.2019.03.016. Epub 2019 Mar 21.
PURPOSE
The aim of this study was to investigate the presence of bacteria in samples of the temporomandibular joint taken from patients suffering from advanced osteoarthritis of the temporomandibular joint (TMJ).
MATERIALS AND METHODS
25 fresh mandibular condyle samples were taken from 17 consecutive patients undergoing mandibular condylectomy (8 bilateral) for advanced TMJ osteoarthritis (Dimitroulis Category 5 joints). The joint samples were stained and cultured for the presence of microorganisms following a standardised joint culture protocol.
RESULTS
No evidence of bacteria was found on staining or solid culture mediums. Late growth (day 12) of commensal skin organisms (P. Acnes, S. Epidermitis, S. Capitis) were identified in enriched broth samples in 5 joint samples. No statistically significant associations were noted between positive broth samples and age or previous joint intervention (p > 0.05) CONCLUSIONS: Within the limitations of this study, we have failed to identify meaningful bacterial growth in tissues (i.e. condylar head) of the TMJ that would suggest a contributory bacterial pathogenesis for arthritis of the TMJ.
目的
本研究旨在调查患有颞下颌关节（TMJ）退行性骨关节炎患者的 TMJ 样本中是否存在细菌。
材料和方法
从 17 名连续接受下颌髁切除术（8 例双侧）的 TMJ 退行性骨关节炎患者（Dimitroulis 第 5 类关节）中采集 25 个新鲜的下颌髁样本。按照标准化的关节培养方案，对关节样本进行染色和培养，以检测微生物的存在。
结果
染色或固体培养基均未发现细菌证据。在 5 个关节样本的富集肉汤样本中，迟发性生长（第 12 天）的共生皮肤微生物（痤疮丙酸杆菌、表皮葡萄球菌、头葡萄球菌）。阳性肉汤样本与年龄或既往关节干预之间无统计学显著关联（p>0.05）。
结论
在本研究的限制范围内，我们未能在 TMJ 的组织（即髁突头部）中发现有意义的细菌生长，这表明 TMJ 关节炎的细菌发病机制可能与之相关。
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