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血管性白塞病合并转换障碍,通过氟脱氧葡萄糖正电子发射断层扫描结合计算机断层扫描(PET/CT)诊断。

Vasculo-Behçet disease complicated by conversion disorder diagnosed with F-fluoro-deoxy-glucose positron emission tomography combined with computed tomography (PET/CT).

作者信息

Furuya Makiko Yashiro, Temmoku Jumpei, Fujita Yuya, Matsuoka Naoki, Asano Tomoyuki, Sato Shuzo, Kobayashi Hiroko, Watanabe Hiroshi, Migita Kiyoshi

机构信息

Department of Rheumatology, Fukushima Medical University School of Medicine.

出版信息

Fukushima J Med Sci. 2019 Aug 30;65(2):55-60. doi: 10.5387/fms.2019-07. Epub 2019 Jul 20.

Abstract

Vasculitis in Behçet's disease, termed "vasculo-Behçet's disease," is a major cause of mortality and morbidity. We report a case of vasculo-Behçet's disease complicated by conversion disorder, in which F-fluoro-deoxy-glucose positron emission tomography combined with computed tomography (FDG PET/CT) was useful for the diagnosis. A twenty-two-year-old woman recently diagnosed with tonsillitis presented with fever, right foot pain, left equinovarus foot, and numbness in both hands and feet. Laboratory data showed elevated levels of c-reactive protein (CRP). The patient was positive for HLA B51; pathergy testing was also positive. Nerve conduction velocity and electromyography were normal. MRI showed swelling of the left crural muscle group. PET/CT showed intense FDG uptake in the left popliteal artery, demonstrating active vasculitis. The patient was diagnosed with vasculo-Behçet's disease and treated with corticosteroids, colchicine, and infliximab, which led to obvious improvement of the MRI findings and reduction in CRP. However, left equinovarus foot and numbness in the extremities persisted. She also developed aphonia. They were attributed to psychogenic dystonia and conversion disorder, and psychiatric treatment was effective in relieving those symptoms. We suggest that PET/CT may be useful for the early diagnosis of medium-sized vessel vasculitis in patients with Behçet's disease.

摘要

白塞病中的血管炎,称为“血管型白塞病”,是导致死亡和发病的主要原因。我们报告一例并发转换障碍的血管型白塞病病例,其中氟脱氧葡萄糖正电子发射断层扫描结合计算机断层扫描(FDG PET/CT)对诊断有帮助。一名22岁近期诊断为扁桃体炎的女性,出现发热、右脚疼痛、左马蹄内翻足以及双手和双脚麻木。实验室数据显示C反应蛋白(CRP)水平升高。患者HLA B51呈阳性;针刺反应试验也呈阳性。神经传导速度和肌电图检查正常。MRI显示左小腿肌群肿胀。PET/CT显示左腘动脉有强烈的FDG摄取,提示存在活动性血管炎。该患者被诊断为血管型白塞病,并接受了皮质类固醇、秋水仙碱和英夫利昔单抗治疗,这使得MRI表现明显改善且CRP降低。然而,左马蹄内翻足和肢体麻木持续存在。她还出现了失音。这些被归因于精神性肌张力障碍和转换障碍,而精神科治疗有效地缓解了这些症状。我们认为PET/CT可能有助于白塞病患者中、小血管血管炎的早期诊断。

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本文引用的文献

1
What Is Vascular Behçet's Disease?什么是血管性白塞病?
Ann Vasc Dis. 2018 Mar 25;11(1):52-56. doi: 10.3400/avd.ra.18-00002.
2
Update on the diagnosis and management of Behçet's disease.白塞病诊断与管理的最新进展
Open Access Rheumatol. 2014 Dec 30;7:1-8. doi: 10.2147/OARRR.S46644. eCollection 2015.
6
Recognizing and treating conversion disorder.识别与治疗转换障碍。
Virtual Mentor. 2008 Mar 1;10(3):158-60. doi: 10.1001/virtualmentor.2008.10.3.cprl1-0803.

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