Suzuki Takehiro, Maekawa Kota, Matsuo Ko, Yamasaki Masayoshi, Shibata Masunari, Takahashi Toshiyuki, Naito Yutaka
Department of Neurology, Ise Red Cross Hospital, Japan.
Department of Neuroendovascular Therapy, Ise Red Cross Hospital, Japan.
Intern Med. 2019 Nov 15;58(22):3319-3321. doi: 10.2169/internalmedicine.2845-19. Epub 2019 Jul 22.
Antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) associated encephalitis is an important syndrome associated with MOG-IgG. However, there have been no reports of MOG-IgG-associated optic neuritis or demyelination following meningitis without encephalitic symptoms. A 55-year-old woman presented to our hospital with headache, nausea, fever, and nuchal rigidity that had persisted for more than a month. She was hospitalized due to aseptic meningitis and recovered with conservative therapy. However, she was re-admitted due to left optic neuritis and demyelinating lesions. We diagnosed MOG-IgG-associated neuromyelitis optica spectrum disorder (NMOSD). She responded to treatment with intravenous methylprednisolone and oral prednisolone. Aseptic meningitis may be an initial manifestation of MOG-IgG-positive NMOSD.
抗髓鞘少突胶质细胞糖蛋白（MOG-IgG）相关脑炎是一种与MOG-IgG相关的重要综合征。然而，尚无关于无脑炎症状的脑膜炎后MOG-IgG相关视神经炎或脱髓鞘的报道。一名55岁女性因头痛、恶心、发热和颈部强直持续一个多月前来我院就诊。她因无菌性脑膜炎住院，经保守治疗后康复。然而，她因左眼视神经炎和脱髓鞘病变再次入院。我们诊断为MOG-IgG相关视神经脊髓炎谱系障碍（NMOSD）。她对静脉注射甲基泼尼松龙和口服泼尼松龙治疗有反应。无菌性脑膜炎可能是MOG-IgG阳性NMOSD的初始表现。
