Karimzadeh Parvaneh, Tabrizi Aydin
Department of Pediatric Neurology, Mofid Children's Hospital, Faculty of Medicine, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Department of Pediatric Neurology, Pediatric Neurology Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Child Neurol. 2019 Summer;13(3):7-24.
Epilepsy, in children, is a common neurological problem for referral to child neurology clinics. The prevalence of nonfebrile seizure in children (under 10 years old), is estimated from 5.2 to 8.1 per 1000. Also, the prevalence of epilepsy in Iran estimated about 5 %; it means 4 million people of Iranian population live with epilepsy in Iran. Although antiseizure drugs (ASDs) are the essential treatment modalities in most children, more than 30% of epileptic children have intractable seizures or they suffer from drug adverse effects secondary to these medications. Because only a limited number of epileptic patients benefit from surgical therapy using the additional therapeutic options is inevitable. There are many available nonpharmacologic proven therapies for refractory seizures that Dietary therapy ( Ketogenic Diet) is one of the important therapeutic options in this group. In this review, we will discuss the different features of pediatric epilepsy dietary therapies (Especially the Ketogenic Diet) in Iran and also the history of epilepsy in ancient Iran, utilization, effectiveness, side effects, tolerability, and acceptability as well as ongoing and future programs.
癫痫在儿童中是一种常见的神经系统问题，常被转诊至儿童神经科诊所。据估计，10岁以下儿童非热性惊厥的患病率为每1000人中有5.2至8.1例。此外，伊朗癫痫的患病率估计约为5%；这意味着伊朗有400万人患有癫痫。尽管抗癫痫药物（ASDs）是大多数儿童的主要治疗方式，但超过30%的癫痫儿童有难治性癫痫发作，或者他们遭受这些药物继发的药物不良反应。由于只有有限数量的癫痫患者能从手术治疗中获益，因此使用其他治疗选择是不可避免的。对于难治性癫痫发作，有许多已被证实的非药物治疗方法，饮食疗法（生酮饮食）是这组治疗方法中的重要选择之一。在这篇综述中，我们将讨论伊朗儿童癫痫饮食疗法（尤其是生酮饮食）的不同特点，以及古代伊朗癫痫的历史、应用、有效性、副作用、耐受性、可接受性以及正在进行和未来的计划。
