哎呀！高尔基体内有一个 ERAD 拟态。
EGAD! There is an ERAD doppelganger in the Golgi.
机构信息
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
出版信息
EMBO J. 2019 Aug 1;38(15):e102679. doi: 10.15252/embj.2019102679. Epub 2019 Jul 22.
Abstract
Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitated by ESCRT-dependent lysosomal degradation. In this issue of The EMBO Journal, Schmidt et al define a previously uncharacterized endosome and Golgi-associated degradation (EGAD) pathway. This pathway, which has remarkable similarities to ERAD in the endoplasmic reticulum, operates in post-ER organelles via the proteasome and contributes to lipid homeostasis in eukaryotic cells.
摘要
膜蛋白在晚期分泌途径中的处理被认为仅由 ESCRT 依赖性溶酶体降解所促进。在本期《EMBO 杂志》中，Schmidt 等人定义了一个以前尚未被描述的内体和高尔基体相关降解（EGAD）途径。该途径与内质网中的 ERAD 具有显著的相似性，通过蛋白酶体在 ER 后细胞器中运作，并有助于真核细胞的脂质稳态。
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