Vanderhoek J Y
Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia 20037.
Ann N Y Acad Sci. 1988;524:240-51. doi: 10.1111/j.1749-6632.1988.tb38547.x.
Recent data from our laboratory, as well as supporting evidence from other investigators, strongly suggest that the PMN 15-LO exists in a cryptic state. Several stimuli, including HETEs, can convert the inactive 15-LO to an active species that can metabolize AA to a variety of products. Many of these metabolites have been reported to modulate various components of the immune response.
我们实验室的最新数据以及其他研究者的支持性证据有力地表明，PMN 15 -脂氧合酶（PMN 15-LO）以一种隐匿状态存在。包括羟二十碳四烯酸（HETEs）在内的几种刺激物，可将无活性的15 -脂氧合酶转化为能将花生四烯酸（AA）代谢为多种产物的活性形式。据报道，这些代谢产物中的许多都能调节免疫反应的各个组成部分。
