Uchiyama K, Takada T, Yasuda H, Hasegawa H, Tsuchiya S, Misu Y, Saitoh Y, Shikata J, Kozakai M
1st Dept. of Surgery, Teikyo University School of Medicine.
Gan To Kagaku Ryoho. 1988 Jun;15(6):1987-90.
A 64-year-old woman who was diagnosed as inoperable intrahepatic bile duct cancer with massive liver metastasis was treated with 5-fluorouracil (5-FU), adriamycin (ADM) and mitomycin-C (MMC). Obstructive jaundice was reduced and performance status was soon improved by this regimen. The reduction rate of the tumor was noted to be more than 50% on CT images, so this patient was considered to have achieved a partial response. In histological examination, well differentiated tubular adenocarcinoma cells were degenerated and replaced fibrous tissue. Thus, it was considered that the reduction of the tumor was caused by these phenomena. This case suggested the activity of 5-FU, ADM and MMC combination for bile duct cancer.
一名64岁女性被诊断为无法手术的肝内胆管癌伴大量肝转移，接受了5-氟尿嘧啶（5-FU）、阿霉素（ADM）和丝裂霉素-C（MMC）治疗。通过该方案，梗阻性黄疸减轻，身体状况很快得到改善。CT图像显示肿瘤缩小率超过50%，因此该患者被认为达到了部分缓解。组织学检查发现，高分化管状腺癌细胞发生退变并被纤维组织取代。因此，认为肿瘤缩小是由这些现象引起的。该病例提示5-FU、ADM和MMC联合应用对胆管癌有活性。
