硫代苹果酸金钠不会阻断兔子体内白细胞介素1的产生。

Sodium aurothiomalate does not block interleukin 1 production in rabbits.

作者信息

Zurovsky Y, Laburn H P, Mitchell D, Ruck A

机构信息

Department of Physiology, University of the Witwatersrand Medical School, Johannesburg, South Africa.

出版信息

Ann Rheum Dis. 1988 Jun;47(6):506-8. doi: 10.1136/ard.47.6.506.

DOI:10.1136/ard.47.6.506

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1003555/

Abstract

Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.

摘要

金盐可通过抑制白细胞介素1的产生来减轻炎症过程。研究表明，向兔子静脉注射两种热原后，硫代苹果酸金钠并无退热作用。因此，它无法抑制白细胞介素1的产生，这一结论在体外淋巴细胞激活因子试验中得到了证实。然而，长期使用硫代苹果酸金钠治疗确实会使血液白细胞计数显著降低。

相似文献

1

Sodium aurothiomalate does not block interleukin 1 production in rabbits.硫代苹果酸金钠不会阻断兔子体内白细胞介素1的产生。

Ann Rheum Dis. 1988 Jun;47(6):506-8. doi: 10.1136/ard.47.6.506.

2

Effects of gold on the production of and response to human interleukin-1.

J Rheumatol. 1987 Dec;14(6):1123-7.

3

Bimodal effect of gold on IL-1 production by blood monocytes.金对血液单核细胞产生白细胞介素-1的双峰效应。

J Rheumatol. 1989 Aug;16(8):1160-1.

4

Effect of auranofin and sodium aurothiomalate on interleukin-1 production from human monocytes in vitro.金诺芬和硫代苹果酸金钠对人单核细胞体外产生白细胞介素-1的影响。

Scand J Rheumatol. 1988;17(4):255-62. doi: 10.3109/03009748809098794.

5

Pharmacologic modulation of TNF production by endotoxin stimulated macrophages: in vitro and in vivo effects of auranofin and other chrysotherapeutic compounds.内毒素刺激巨噬细胞产生肿瘤坏死因子的药理学调节：金诺芬及其他金制剂化合物的体外和体内作用

Agents Actions. 1989 Mar;26(3-4):329-34. doi: 10.1007/BF01967297.

6

The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes.金诺芬和硫代苹果酸金钠对外周血单核细胞的作用。

J Rheumatol. 1982 May-Jun;9(3):366-9.

7

The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis.硫代苹果酸金钠和金诺芬对脂多糖诱导的人血单核细胞白细胞介素-1体外产生的影响：健康受试者与关节炎患者的差异

Clin Exp Immunol. 1990 Mar;79(3):335-40. doi: 10.1111/j.1365-2249.1990.tb08092.x.

8

Effect of aurothiomalate on human mononuclear blood cells cultured in vitro.硫代苹果酸金对体外培养的人单核血细胞的作用。

Acta Pathol Microbiol Scand C. 1976 Oct;84C(5):419-24. doi: 10.1111/j.1699-0463.1976.tb00050.x.

9

Unique properties of auranofin as a potential anti-rheumatic drug.金诺芬作为一种潜在抗风湿药物的独特性质。

Agents Actions. 1986 Oct;19(1-2):109-15. doi: 10.1007/BF01977265.

10

Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-κB.金硫代苹果酸（一种NF-κB抑制剂）的抗炎作用研究

Bull Exp Biol Med. 2011 Jun;151(2):190-3. doi: 10.1007/s10517-011-1286-z.

引用本文的文献

1

The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis.硫代苹果酸金钠和金诺芬对脂多糖诱导的人血单核细胞白细胞介素-1体外产生的影响：健康受试者与关节炎患者的差异

Clin Exp Immunol. 1990 Mar;79(3):335-40. doi: 10.1111/j.1365-2249.1990.tb08092.x.

本文引用的文献

1

Selective concentration and localization of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients.类风湿患者金疗法期间及之后，滑膜及其他组织巨噬细胞中黄金的选择性浓缩与定位。

Ann Rheum Dis. 1976 Dec;35(6):477-86. doi: 10.1136/ard.35.6.477.

2

Effect of aurothiomalate on human mononuclear blood cells cultured in vitro.硫代苹果酸金对体外培养的人单核血细胞的作用。

Acta Pathol Microbiol Scand C. 1976 Oct;84C(5):419-24. doi: 10.1111/j.1699-0463.1976.tb00050.x.

3

The macrophage as a secretory cell in chronic inflammation.巨噬细胞作为慢性炎症中的分泌细胞。

Agents Actions. 1976 Feb;6(1-3):60-74. doi: 10.1007/BF01972187.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。