硫代苹果酸金钠不会阻断兔子体内白细胞介素1的产生。
Sodium aurothiomalate does not block interleukin 1 production in rabbits.
作者信息
Zurovsky Y, Laburn H P, Mitchell D, Ruck A
机构信息
Department of Physiology, University of the Witwatersrand Medical School, Johannesburg, South Africa.
出版信息
Ann Rheum Dis. 1988 Jun;47(6):506-8. doi: 10.1136/ard.47.6.506.
Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.
金盐可通过抑制白细胞介素1的产生来减轻炎症过程。研究表明，向兔子静脉注射两种热原后，硫代苹果酸金钠并无退热作用。因此，它无法抑制白细胞介素1的产生，这一结论在体外淋巴细胞激活因子试验中得到了证实。然而，长期使用硫代苹果酸金钠治疗确实会使血液白细胞计数显著降低。
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