IEEE Trans Biomed Eng. 2020 Apr;67(4):1040-1049. doi: 10.1109/TBME.2019.2928645. Epub 2019 Jul 15.
The purpose of this work is to assess the ability of sine waves to perform electrochemotherapy (ECT) and to study the dependence of the frequency of the applied sine wave on the treatment efficacy.
A subcutaneous tumor model in mice was used, and the electric field was delivered in combination with bleomycin. Sinusoidal electric fields of different frequencies, amplitudes, and durations were compared to square waves. Computer simulations were additionally performed.
The results confirmed the ability of a sinusoidal electric field to obtain successful ECT responses. A strong dependence on frequency was obtained. The efficacy of the treatment decreased when the frequency of the sine waves was increased. At low sinusoidal frequency, the efficacy of the treatment is very similar to that obtained with a square wave. The collateral effects such as skin burns and muscle contractions decreased for the highest frequency assayed.
The use of sine wave burst represents a feasible option for the treatment of cancer by ECT.
These results could have important implications for the treatment of cancer in the clinical world where ECT is performed with dc square pulses.
本研究旨在评估正弦波进行电化学治疗（ECT）的能力，并研究施加正弦波的频率对治疗效果的依赖性。
采用小鼠皮下肿瘤模型，联合博来霉素进行电场治疗。将不同频率、幅度和持续时间的正弦波与方波进行比较。此外还进行了计算机模拟。
结果证实了正弦电场获得成功 ECT 反应的能力。结果显示出与频率的强依赖性。随着正弦波频率的增加，治疗效果降低。在较低的正弦频率下，治疗效果与方形波非常相似。对于所检测到的最高频率，皮肤灼伤和肌肉收缩等副作用会降低。
正弦波爆发的使用为 ECT 治疗癌症提供了一种可行的选择。
这些结果对于在临床中使用直流方波脉冲进行 ECT 的癌症治疗具有重要意义。
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