Rudenskiĭ A Iu, Gorokhovets N V, Iurin V L
Biull Eksp Biol Med. 1988 May;105(5):565-7.
In vitro MHC restriction of antigen-specific T-cell proliferation to Igk-Ib allotype of Igk chain has been studied in inbred August rats, using polyclonal and monoclonal antibodies to RT-1 molecules. Igk-1b-specific proliferation of immune T cells was completely abrogated by alloantiserum specific for RT-1c (August) molecules. Monoclonal antibodies (MAb) to RT-1B ("1-A-like") molecules inhibited markedly the response (about 70-80% inhibition), while anti-RT-ID ("I-E-like") MAb caused but weak inhibition (about 25%). Thus, the data obtained demonstrate RT-1Bc molecule as a main restriction element of Igk-1b-specific T-cell response.
利用针对RT-1分子的多克隆和单克隆抗体，在近交系奥古斯特大鼠中研究了抗原特异性T细胞对Igκ链Igκ-Ib同种异型的体外MHC限制。对RT-1c（奥古斯特）分子具有特异性的同种抗血清完全消除了免疫T细胞的Igκ-1b特异性增殖。针对RT-1B（“1-A样”）分子的单克隆抗体（MAb）显著抑制了该反应（约70-80%的抑制率），而抗RT-ID（“I-E样”）MAb仅引起微弱的抑制（约25%）。因此，所获得的数据表明RT-1Bc分子是Igκ-1b特异性T细胞反应的主要限制元件。
