异环磷酰胺/美司钠相关脑病：一例报告及苯巴比妥可能增强神经毒性的作用

Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.

作者信息

Ghosn M, Carde P, Leclerq B, Flamant F, Friedman S, Droz J P, Hayat M

机构信息

Institut Gustave-Roussy, Villejuif, France.

出版信息

Bull Cancer. 1988;75(4):391-2.

PMID:3132998

Abstract

A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.

摘要

报告了一名15岁癫痫女孩在一剂异环磷酰胺/美司钠治疗后出现可逆性脑病的病例。没有其他病理情况可解释这些症状。讨论了癫痫或长春新碱诱导的毒性。然而，已知可诱导肝微粒体活性的苯巴比妥的可能作用似乎是更有可能的机制。