Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Medical Statistics, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Nutrients. 2019 Jul 21;11(7):1670. doi: 10.3390/nu11071670.
To evaluate the relationship between gastric emptying (GE) time and days to achievement of full enteral feeding (≥140 mL/kg/day) in preterm infants randomly assigned to receive one of two marketed study formulas for the first 14 feeding days: intact protein premature formula (IPF) or extensively hydrolyzed protein (EHF) formula.
In this triple-blind, controlled, prospective, clinical trial, we report GE time (time to half-emptying, t) by real-time ultrasonography on Study Day 14, in preterm infants receiving IPF or EHF formula. The association between GE time and achievement of full enteral feeding was evaluated by Pearson correlation. Per-protocol populations for analysis included participants who (1) completed the study (overall) and (2) who received ≥ 75% study formula intake (mL/kg/day).
Median GE time at Day 14 was significantly faster for the EHF vs. IPF group overall and in participants who received ≥ 75% study formula intake ( ≤ 0.018). However, we demonstrated GE time had no correlation with the achievement of full enteral feeding ( = 0.08; = 0.547).
Feeding IP premature formula vs. EH formula was associated with shorter time to full enteral feeding. However, faster GE time did not predict feeding success and may not be a clinically relevant surrogate for assessing feeding tolerance.
评估早产儿在接受两种市售研究配方中的一种进行最初 14 天喂养时，胃排空（GE）时间与达到全肠内喂养（≥140 毫升/千克/天）天数之间的关系。方法：在这项三盲、对照、前瞻性临床试验中，我们报告了在第 14 天接受 IPF 或 EHF 配方的早产儿通过实时超声检查的 GE 时间（排空一半的时间，t）。通过 Pearson 相关性评估 GE 时间与达到全肠内喂养的相关性。分析的按方案人群包括（1）完成研究的参与者（总体）和（2）接受≥75%研究配方摄入量（毫升/千克/天）的参与者。结果：在总体和接受≥75%研究配方摄入量（≤0.018）的参与者中，EHF 组第 14 天的中位 GE 时间明显快于 IPF 组。然而，我们发现 GE 时间与达到全肠内喂养无相关性（=0.08；=0.547）。结论：与 EH 配方相比，喂养 IP 早产儿配方与更快达到全肠内喂养相关。然而，更快的 GE 时间并不能预测喂养成功，并且可能不是评估喂养耐受性的临床相关替代指标。
