Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty of the Heidelberg University, 68167 Mannheim, Germany.
Department of Health Sciences, University of York, Heslington, York YO10 5DDY, UK.
Nutrients. 2019 Jul 19;11(7):1653. doi: 10.3390/nu11071653.
Although there is a growing number of early childhood obesity prevention programs, only a few of them are effective in the long run. Even fewer reports exist on lifetime cost-effectiveness of early prevention strategies. This paper aimed to assess the lifetime cost-effectiveness of infant feeding modification aiming at reducing risk of later obesity.
The simulation model consists of two parts: (a) Model I used data from the European Childhood Obesity Project (CHOP) trial (up to 6 years) and the German Interview and Examination Survey for Children (KiGGS) (6-17 years) to evaluate BMI trajectories of infants receiving either lower protein (LP) or higher protein (HP) content formula; and (b) Model II estimated lifetime cost-effectiveness based on Model I BMI trajectories. Compared to HP formula, LP formula feeding would incur lower costs that are attributable to childhood obesity across all decades of life.
Our analysis showed that LP formula would be cost-effective in terms of a positive net monetary benefit (discounted 3%) as an obesity prevention strategy. For the 19% of infants fed with formula in Germany, the LP strategy would result in cost savings of € 2.5 billion.
Our study is one of the first efforts to provide much-needed cost-effectiveness evidence of infant feeding modification, thereby potentially motivating interventionists to reassess their resource allocation.
尽管有越来越多的儿童期肥胖预防计划，但从长远来看，只有少数计划有效。关于早期预防策略的终身成本效益的报告就更少了。本文旨在评估旨在降低日后肥胖风险的婴儿喂养方式改变的终身成本效益。
该模拟模型由两部分组成：(a)模型 I 使用了欧洲儿童肥胖项目 (CHOP) 试验（最多 6 年）和德国儿童访谈和体检调查 (KiGGS)（6-17 岁）的数据，以评估接受低蛋白 (LP) 或高蛋白 (HP) 含量配方的婴儿的 BMI 轨迹；(b)模型 II 根据模型 I 的 BMI 轨迹来估计终身成本效益。与 HP 配方相比，LP 配方喂养会在整个生命数十年中因儿童肥胖而导致更低的成本。
我们的分析表明，LP 配方作为一种肥胖预防策略，从净货币收益（贴现 3%）的角度来看具有成本效益。对于德国 19%的用配方奶喂养的婴儿，LP 策略将节省 25 亿欧元的成本。
我们的研究是首次提供婴儿喂养方式改变的成本效益的必要性证据的努力之一，从而有可能促使干预者重新评估其资源分配。
