Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-0016, Japan.
BMC Cancer. 2019 Jul 22;19(1):720. doi: 10.1186/s12885-019-5942-4.
Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes.
A 66-year-old man presented with a fever and dyspnea after treatment with cabazitaxel for castration-resistant prostate cancer. He was treated with an intravenous broad-spectrum antimicrobial agent, however he complained of dyspnea and had a pulse oximetric saturation of 80% while breathing room air. The patients had been treated for bone metastases with 37.5 Gy to the thoracic spine (Th 7) as a local radiotherapy. Radiological images showed pulmonary interstitial opacities in the irradiated field of the both lungs. The steroid pulse therapy was started. The patient's dyspnea disappeared and the interstitial opacities had also improved.
This report is a case of interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy.
间质性肺炎是在接受紫杉醇类抗癌药物治疗后，肺部或胸部病变的先前照射区域出现的罕见反应。
一名 66 岁男性在接受卡巴他赛治疗去势抵抗性前列腺癌后出现发热和呼吸困难。他接受了静脉广谱抗菌药物治疗，但他主诉呼吸困难，在呼吸室内空气时脉搏血氧饱和度为 80%。患者曾因骨转移接受过局部放疗，胸 7 椎体 37.5Gy 照射。影像学图像显示双肺照射野有肺间质混浊。开始使用类固醇脉冲治疗。患者的呼吸困难消失，间质混浊也有所改善。
本报告是一例接受卡巴他赛治疗的去势抵抗性前列腺癌患者在胸部放疗后发生间质性肺炎的病例。
