了解你的肾小球滤过率——什么时候数字并不（完全）是数字？

Knowing your GFR-when is the number not (exactly) the number?

机构信息

Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.

出版信息

Kidney Int. 2019 Aug;96(2):280-282. doi: 10.1016/j.kint.2019.03.026.

DOI:10.1016/j.kint.2019.03.026

Abstract

All methods used to measure and estimate glomerular filtration rate (GFR) are associated with systematic or random error, which leads to differences in measured GFR (mGFR) and estimated GFR (eGFR) from "true GFR." In this issue of Kidney International, Rowe et al. evaluate time-to-time variability using repeated assessments of mGFR and eGFR within a short time frame. They show that biological variability is larger for mGFR than eGFR, and the magnitude of reference change values when interpreting changes in mGFR and eGFR.

摘要

所有用于测量和估计肾小球滤过率（GFR）的方法都与系统或随机误差相关，这导致测量的 GFR（mGFR）和估计的 GFR（eGFR）与“真实 GFR”存在差异。在本期《国际肾脏杂志》中，Rowe 等人评估了在短时间内通过重复评估 mGFR 和 eGFR 来评估时间变化的情况。他们表明，mGFR 的生物学变异性大于 eGFR，并且在解释 mGFR 和 eGFR 变化时参考变化值的幅度也较大。