Servicio de Radiodiagnóstico, Hospital Universitario Santiago de Compostela, Santiago de Compostela (La Coruña), España.
Servicio de Neurología, Complejo Hospitalario Universitario Pontevedra, Pontevedra, España.
Neurologia (Engl Ed). 2022 Jul-Aug;37(6):421-427. doi: 10.1016/j.nrl.2019.04.004. Epub 2019 Jul 19.
Calcified cerebral embolism (CCE), a rarely reported and underdiagnosed cause of stroke, may be the first manifestation of a vascular or cardiac disease. Our purpose is to describe the characteristics of CCE in a series of 9 cases and review the literature on the subject.
We included patients with CCE from 3 different hospitals. We described the diagnostic approach, neuroimaging findings, origin of the embolism, treatment, and prognosis of these patients.
We identified a total of 9 patients presenting spontaneous CCE as the cause of acute ischaemic stroke. In all cases, the middle cerebral artery was affected; all patients underwent CT. A possible calcific source was found in 6 patients (66.6%), originated in the carotid arteries in 3 (33.3%) and in the heart in the other 3 patients (33.3%). Only one patient was treated in the acute phase (trombectomy) and only 11% of patients had modified ranking scale scores ≤ 2 at 3 months.
CCE is more frequent than previously thought and, although the condition continues to be underdiagnosed, it is of considerable prognostic relevance in the aetiological study of stroke.
钙化性脑栓塞（CCE）是一种罕见且易漏诊的中风病因，可能是血管或心脏疾病的首发表现。本研究旨在通过 9 例病例系列描述 CCE 的特征，并复习该主题的文献。
我们纳入了来自 3 家不同医院的 CCE 患者。我们描述了这些患者的诊断方法、神经影像学表现、栓塞起源、治疗和预后。
我们共发现 9 例自发 CCE 引起的急性缺血性中风患者。所有患者均行 CT 检查，均影响大脑中动脉；6 例（66.6%）发现了可能的钙化源，3 例（33.3%）起源于颈动脉，3 例（33.3%）起源于心脏。仅有 1 例在急性期接受了治疗（血栓切除术），3 个月时改良 Rankin 量表评分≤2 的患者仅占 11%。
CCE 比先前认为的更为常见，尽管该病症仍存在漏诊，但在中风病因学研究中具有重要的预后意义。
