Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK.
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK; Department of Neurosurgery, Level 3, The West Wing, John Radcliffe Hospital, Oxford, UK.
J Clin Neurosci. 2019 Oct;68:342-343. doi: 10.1016/j.jocn.2019.07.037. Epub 2019 Jul 19.
The periaqueductal grey area and sensory thalamus are thought to be important nuclei involved in the supraspinal bladder control network. Deep brain stimulation of the periqueductal grey area has been shown to increase bladder capacity in the human. In a single patient, we have recorded local field potential signals from implanted deep brain stimulation electrodes within the sensory thalamus during filling cystometry with periaqueductal grey area deep brain stimulation in the ON and OFF states. In the OFF stimulation state, we demonstrate correlations between bladder volume and oscillations in the high gamma frequency band in the sensory thalamus. Stimulation of the periaqueductal grey area abolishes this correlated activity in the gamma frequency band and also suppresses oscillations within the sensory thalamus in the alpha frequency band. These findings support the involvement of the sensory thalamus in the afferent limb of bladder-related brain networks. They also suggest that periaqueductal grey area deep brain stimulation may disrupt the normal processing of afferent signals within the sensory thalamus which may be related to the effect of stimulation on bladder capacity.
导水管周围灰质区和感觉丘脑被认为是参与脊髓上膀胱控制网络的重要核团。研究表明，导水管周围灰质区深部脑刺激可增加人类的膀胱容量。在一名患者中，我们在导水管周围灰质区深部脑刺激开启和关闭状态下进行充盈性膀胱测压时，记录了感觉丘脑内植入深部脑刺激电极的局部场电位信号。在关闭刺激状态下，我们证明了膀胱容量与感觉丘脑内高频伽马频段的振荡之间存在相关性。导水管周围灰质区刺激消除了伽马频段的这种相关活动，并抑制了感觉丘脑内的阿尔法频段的振荡。这些发现支持感觉丘脑参与与膀胱相关的脑网络的传入支。它们还表明，导水管周围灰质区深部脑刺激可能会破坏感觉丘脑内传入信号的正常处理，这可能与刺激对膀胱容量的影响有关。
