Faculty of Medicine, University of Oulu, Oulu, Finland.
Medical Informatics and Statistics Research Group, University of Oulu, Oulu, Finland.
Occup Environ Med. 2019 Oct;76(10):765-771. doi: 10.1136/oemed-2018-105606. Epub 2019 Jul 22.
To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival.
The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The BAL cell differential counts were analysed in relation to smoking status. BAL cell differential counts and the number of ABs were correlated with the patients' survivals.
A neutrophilic cell pattern was observed independently of smoking habits with both Papanicolau (8.4%) and May-Grunwald-Giemsa (6.5%) staining. Smoking and a high number of ABs (>2 AB/mL) were associated with high total cell counts and high macrophage and low lymphocyte differential counts. The median survival of the patients was 131.8 months. Shortened survival was associated with high numbers of ABs (78 vs 165 months; p=0.042) and low lymphocyte (77 vs 179 months; p=0.005), high neutrophil (102 vs 180 months; p=0.016) and high eosinophil (104 vs170 months; p=0.007) differential counts.
A neutrophilic cell pattern was evident in BAL from patients with asbestosis. Smoking and ABs both affected the total cell count and the macrophage and lymphocyte differential counts. Several BAL parameters associated with patient survival, suggesting that BAL cell count analyses could be used in the estimation of the prognosis of patients with asbestosis.
确定石棉肺患者支气管肺泡灌洗液（BAL）中的细胞差异计数和石棉体（AB）数量，并将结果与他们的生存情况相关联。
确定了 91 例石棉肺患者的 BAL 细胞差异计数和 AB。分析了 BAL 细胞差异计数与吸烟状况的关系。BAL 细胞差异计数和 AB 数量与患者的存活率相关。
无论吸烟习惯如何，用巴氏和迈-格努姆染色都观察到中性粒细胞模式。吸烟和大量 AB（>2 AB/mL）与总细胞计数高、巨噬细胞计数高、淋巴细胞计数低有关。患者的中位生存期为 131.8 个月。AB 数量高（78 与 165 个月；p=0.042）和淋巴细胞计数低（77 与 179 个月；p=0.005）、中性粒细胞计数高（102 与 180 个月；p=0.016）和嗜酸性粒细胞计数高（104 与 170 个月；p=0.007）与生存期缩短相关。
石棉肺患者的 BAL 中存在中性粒细胞模式。吸烟和 AB 均影响总细胞计数和巨噬细胞和淋巴细胞差异计数。一些与患者生存相关的 BAL 参数，表明 BAL 细胞计数分析可用于估计石棉肺患者的预后。
