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依替巴塞（Lysin CF-301）对感染性心内膜炎最常见病因的抗菌活性。

Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis.

机构信息

ContraFect Corporation, Yonkers, New York, USA.

Antimicrobial Development Specialists, LLC, Nyack, New York, USA.

出版信息

Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.01078-19. Print 2019 Oct.

DOI:10.1128/AAC.01078-19
PMID:31332073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6761524/
Abstract

Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of and spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all spp. tested, including and coagulase-negative staphylococci (MIC, 0.5/1 μg/ml). Activity against spp. was variable, with , , and (MIC, 1/2 μg/ml) among the most susceptible.

摘要

依巴斯汀（一种重组溶菌酶，细胞壁水解酶）和对照抗生素采用肉汤微量稀释法检测了和 属，这些是人类感染性心内膜炎最常见的病原体。依巴斯汀对所有测试的 属均具有活性，包括 和凝固酶阴性葡萄球菌（MIC，0.5/1μg/ml）。对 属的活性存在差异，其中 、 和 （MIC，1/2μg/ml）最敏感。

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Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.02616-18. Print 2019 Jun.
2
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J Antimicrob Chemother. 2019 May 1;74(5):1306-1310. doi: 10.1093/jac/dkz006.
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The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Bacteriolysis.抗葡萄球菌溶素 CF-301 在人血中激活关键宿主因子增强耐甲氧西林金黄色葡萄球菌裂解。
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.02291-18. Print 2019 Apr.
4
Infective Endocarditis.感染性心内膜炎
Emerg Med Clin North Am. 2018 Nov;36(4):645-663. doi: 10.1016/j.emc.2018.06.002.
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