Drake M E
Department of Neurology, Ohio State University College of Medicine, Columbus.
Eur Neurol. 1988;28(3):174-6. doi: 10.1159/000116260.
Lupus anticoagulant is more often associated with thromboembolism than hemorrhage. We have observed two cases of lupus anticoagulant associated with basal ganglion lacunar infarction, causing contralateral choreoathetosis. One patient had no evidence of lupus or other etiology, and responded to antiplatelet therapy, while the other was found to have systemic lupus erythematosus with nephritis and was successfully treated with steroids. The effects of lupus anticoagulant on platelet prostacyclin receptors or prostacyclin production, or its effect on cerebral vessels may permit small-vessel occlusion and lacunar infarction in susceptible patients.
狼疮抗凝物与血栓形成的关联比与出血的关联更为常见。我们观察到两例狼疮抗凝物与基底节腔隙性梗死相关的病例，导致对侧舞蹈手足徐动症。其中一例患者无狼疮或其他病因的证据，对抗血小板治疗有反应，而另一例患者被发现患有系统性红斑狼疮伴肾炎，经类固醇治疗成功。狼疮抗凝物对血小板前列环素受体或前列环素生成的影响，或其对脑血管的影响，可能使易感患者发生小血管闭塞和腔隙性梗死。
